强的松联合吗替麦考酚酯治疗血管炎型IgA肾病的疗效及对血清中转化生长因子β_1的影响  

Efficacy observation and TGF-β_1 detection in patients with vasculitis type IgA nephropathy treated by mycophenolate mofetil and prednisone.

作　　者：何川鄂[1] 杨林[1,2] 杨芦蓉[1] 李丽华[1] 张祥文[1,2] 夏敬彪[1,2] 

机构地区：[1]宜昌市中心人民医院肾脏科,湖北宜昌443003 [2]三峡大学第一临床医学院,湖北宜昌443003

出　　处：《海南医学》2013年第3期318-320,共3页Hainan Medical Journal

摘　　要：目的探讨强的松联合吗替麦考酚酯治疗血管炎型IgA肾病的疗效及对血清中转化生长因子β1(TGF-β1)的影响。方法收集我院确诊的88例血管炎型IgA肾病,依患者的入院顺序分为观察组与对照组,观察组44例,在常规治疗基本上加用强的松联合吗替麦考酚酯治疗;对照组44例,在常规治疗基础上加用强的松治疗,观察治疗的效果及治疗前、治疗后血清中TGF-β1的变化。结果观察组的疗效明显优于对照组(93.18%vs77.27%),两组患者治疗后血清中TGF-β1的含量均下降,但是观察组患者的下降值明显高于对照组[(65.08±8.63)ng/Lvs(40.89±8.32)ng/L]。结论强的松联合吗替麦考酚酯治疗血管炎型IgA肾病患者临床疗效明显,且能显著降低血清中TGF-β1的含量,值得临床推广应用。Objective To observe the curative effect, TGF-β1 change in patients with vasculitis type IgA ne-phropathy treated by mycophenolate mofetil and prednisone. Methods Eighty-eight patients with vasculitis type IgA nephropathy were divided into two groups. The control group （44 cases） were treated by routine treatment and predni-sone, the observation group （44 cases） were added mycophenolate mofetil and prednisone. We observated the efficacy and the change of TGF-β1l in two groups. Results The total effective rate was obviously higher in the observation group than that in the control group （93.18% vs 77.27%）. The change value of TGF-β1 were obviously higher in the observation group after treatment [（65.08±8.63） ng/L vs （40.89±8.32） ng/L]. Conclusion Mycophenolate mofetil and prednisone can improve the curative effect, regulate the expression of TGF-β1 in patients with vasculitis type IgA nephropathy.

关 键 词：强的松 吗替麦考酚酯 血管炎型IgA肾病 转化生长因子-Β1 

分 类 号：R692[医药卫生—泌尿科学]