苗药香囊对正常小鼠肺泡灌洗液及血清IL-2、IL-18水平的影响  

Effect of Miaoyaoxiangnang on IL-2 and IL-18 in fluid of bronchoalveolar lavage and serum of normal mice

作　　者：孟庆志[1,2] 程明亮[1] 张权[1] 王豫萍[1] 李绍臣[2] 

机构地区：[1]贵阳医学院附属医院感染科,贵阳市550004 [2]河北省廊坊市人民医院,廊坊市065000

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第6期5-7,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的观察苗药香囊对正常小鼠肺泡灌洗液及血清IL-2、IL-18水平的影响。方法雄性昆明小鼠50只,随机分为5组,即空白对照组、玉屏风颗粒组(阳性对照组)、香囊持续吸入组、香囊间断吸入组和香囊持续吸入+玉屏风颗粒组(香+玉组)。连续用药1个月后采用ELISA试剂盒检测灌洗液及血清中IL-2、IL-18水平的变化。结果香囊持续吸入组肺泡灌洗液IL-2和IL-18的含量分别为(90.99±10.27)pg/ml和(175.29±71.60)pg/ml,显著高于空白对照组的(54.08±23.49)pg/ml和(85.66±28.19)pg/ml,差异具有统计学意义(P<0.05)。结论苗药香囊能够增加正常小鼠呼吸道中IL-2和IL-18的含量,进而增强正常小鼠呼吸道黏膜的局部免疫功能。Objective To observe the influences of miaoyaoxiangnang on secretory interleukin 2 （IL-2） and interleukin 18 （ IL-18 ） in fluid of bronchoalveolar lavage and serum of healthy mice. Methods Total of 50 kunming mice were randomly divided into normal control （NC） group, yupingfengkeli （YPFKL） group, continuous inhalation of xiangnang （CIOXN） group, intermittent inhalation of xiangnang （IIOXN） group, CIOXN ＋ YPFKL group （n = 9 in each group）. All mice in 5 groups were treated for one month. The levels of LX-2 and IL-18 in fluid of bronchoalveolar lavage and serum were detected by an ELISA kit, respectively. Results Compared with NC group, the levels of IL-2 and IL-18 in fluid of bronchoalveolar lavage in CIOXN group were significantly higher （ P 〈 0.05 ）. Conclusions Miaoyaoxiangnang could enhance the levels of IL-2 and IL-18 in the respiratory tract of healthy mice, which may mainly increase the respratory mucosal immune function of the mouse.

关 键 词：苗药香囊 流感 小鼠 

分 类 号：R29[医药卫生—民族医学]