外周血白细胞计数对肥胖者发生代谢综合征的预测价值  

The Value of Peripheral White Blood Cell Counts on Predicting the Occurrence of Metabolic Syndrome in Obesity

作　　者：熊璞[1,2] 张弛[1,2] 赵乃蕊[1,2] 李华珠[1,2] 杨晓春[1,2] 周桂莲[1,2] 王敏[1,2] 王霞[1,2] 陈晶[1,2] 刘瑛[1,2] 

机构地区：[1]湖南省人民医院 [2]湖南师范大学第一附属医院内分泌科,湖南长沙410005

出　　处：《现代生物医学进展》2012年第35期6887-6889,共3页Progress in Modern Biomedicine

基　　金：湖南省科技计划项目(2011SK3160)

摘　　要：目的:探讨正常范围内外周血白细胞计数(peripheral white blood cell counts,WBCC)对肥胖者发生代谢综合征(metabolicsyndrome,MS)的预测价值。方法:收集湖南省人民医院体检中心2006年4月～2010年1月体检人群共4067例,排除资料不全者,共2830例纳入研究。其中1367例于1～3年后再次来我院体检。肥胖诊断标准按照2000年国际肥胖工作组规定的亚太地区肥胖标准,其中共有肥胖者1120例。代谢综合征诊断标准采用2004年中华医学会糖尿病学分会关于MS的定义。将325例WBCC正常的肥胖者进行四分位数分组(Q1～Q4),随访1～3年后,比较不同WBCC组别发生MS的风险。结果:1.在1120例肥胖体检人群中,肥胖伴MS者352例,占31.43%。2.325例WBCC正常的肥胖者进行四分位数分组(Q1～Q4),随访1～3年后,Q4组发生MS的风险明显增高(25.32%vs 11.11%,OR=2.712;95%CI:1.149-6.400,P<0.05)。结论:1).肥胖人群中,肥胖伴MS者占31.43%。2).正常范围内WBCC的升高可预测肥胖者MS的发生。Objective： To investigate the value of peripheral white blood cell counts（WBCC） in normal range on predicting metabolic syndrome in obesity.Methods： 4076 subjects were evaluated for routine health examination in People＇s Hospital of Hunan ProvincefromApril2006toJanuary2010,2830individualswereenrolledexcludingthosewithmissingdata.1367individualswerefollowed up during 1～3 years.Obesity was diagnosed according to the criteria of the Asia-Pacific region of international obesity task force（IOTF） in 2000,1120 individuals were obese.Metabolic Syndrome（MS） was diagnosed according to the critetia of Chinese Diabetes Society（CDS） in 2004.325 obesity without MS with normal WBCC were divided into four groups according to quartile of WBCC,following up for 1 to 3 years,compare the risk of incident MS in different groups of quartile of WBCC.Results： 1.The percentage of MS in obesity was 31.43%（352/1120）.2.325 obesity without MS with normal WBCC were divided into four groups according to quartile of WBCC（Q1～Q4）,the incidence of MS in the highest quartile of WBCC（Q4） was significantly increased（OR=2.712;95% CI： 1.149-6.400,P0.05）.Conclusions： 1.The percentage of MS in obesity was 31.43%.2.Even in the normal range,the elevated WBCC could predicte the risk of incident MS in obesity.

关 键 词：肥胖 代谢综合征(MS) 外周血白细胞计数(WBCC) 

分 类 号：R589.2[医药卫生—内分泌]