喀什地区维吾尔族和汉族丙肝实验室检查的对比分析  

A Comparative Analysis of Hepatitis C Laboratory Tests in Uygur and Han in Kashgar Region

作　　者：张丽萍[1] 崔秀菊 杜希利[1] 周慧芳[1] 刘雯[1] 

机构地区：[1]新疆喀什地区第一人民医院检验科,新疆喀什844000 [2]新疆喀什地区泽普县人民医院检验科,新疆喀什844800

出　　处：《现代生物医学进展》2012年第35期6930-6932,6886,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨喀什地区维吾尔族和汉族丙肝患者的实验室检查特征,为临床诊断治疗提供依据。方法:对424例丙肝患者血清采用酶联免疫吸附法检测抗-HCV,荧光定量聚合酶链反应法检测丙肝RNA,采用电化学发光法检测FER、CA125、CA199,采用酶法检测GGT,ALT,AST。结果:维吾尔族丙肝患者HCVRNA的阳性率65.25%明显高于汉族患者54.26%,且维吾尔族丙肝患者血清FER(476.35±120.50)和GGT(71.22±21.84)水平均高于汉族患者FER(333.44±105.71)、GGT(55.63±15.16),差异均有统计学意义(P<0.05)。但两民族患者间抗-HCV阳性率、CA125、CA199、ALT、AST水平无统计学差异(P>0.05)。结论:喀什地区维吾尔族和汉族丙肝患者不同,维吾尔族丙肝患者HCVRNA阳性率、FER、GGT水平均高于汉族患者,本研究提示维吾尔族丙肝患者可能肝细胞损害较重,更易发展为肝癌,临床应加以重视。Objective： To explorethecharacteristicsoflaboratorytestsin hepatitisC in KashgarUygurand Han patients,and provide the basis for clinical diagnosis and treatment.Methods： For 424 cases of Hepatitis C,Serum levels of antibody of HCV were detected by Enzyme-linked immunosorbent assay,HCV-RNA were detected by fluorescence quantitative polymerase chain reaction,Ferritin,CA125 and CA199 were detected by electrochemiluminescence method,GGT,ALT and AST were detected by enzymatic method.Results： The positive rate of HCV-RNA were markedly higher in Uygur patients（65.25%）than Han patients（54.26%）,and the serum levels of FER and GGT were markedly higher in Uygur patients（476.35±120.50）（71.22±21.84）than Han patients（333.44±105.71）（55.63±15.16）,and there were significant differences（P0.05）.For the positive rate of antibody of HCV,the levels of CA125,CA199,ALT,and AST,there was no significant difference between Uygur patients and Han patients（p0.05）.Conclusions： There were differences in hepatitis C between Uygur and Han in Kashgar region in XinJiang,the positive rate of HCV-RNA,the level of FER and GGT were markedly higher in Uygur patients than in Han patients.Our study suggest liver cell damage of Uygur patients with hepatitis C was more serious,and they were more likely to develop liver cancer,and we in clinic should pay attention to the characteristics.

关 键 词：抗-HCV 丙肝RNA 铁蛋白 γ-谷氨酰胺转肽酶 

分 类 号：R512.63[医药卫生—内科学]