冠心病患者血浆和肽素、白细胞介素18的表达及临床意义  

The Changes of the Copeptin and Interleukin 18 in Coronary Heart Patients and its Significance

作　　者：王丽[1] 滕晓梅[1] 权翠侠 霍美凤[1] 范乐明[2] 

机构地区：[1]徐州市第一人民医院检验科,江苏徐州221000 [2]南京医科大学基础医学院,江苏南京210029

出　　处：《现代生物医学进展》2012年第35期6933-6935,6923,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨血浆hs-CRP、IL-18及和肽素(copeptin)与冠心病类型的关系及临床意义。方法:36例对照组,41例稳定型心绞痛(SA)组,43例不稳定性心绞痛(UA)组,48例急性心肌梗死(AMI)组,均符合缺血性心肌病的诊断标准。采用免疫比浊法测定hs-CRP水平;采用放射免疫法测定血浆和肽素;采用双抗体夹心ELISA法测定血浆IL-18水平。结果:UA组与AMI组WBC、NEU、hs-CRP、IL-18、和肽素水平显著高于正常对照组(P<0.05);与UA组比较,AMI组的hs-CRP、IL-18水平显著升高;IL-18与TG、LDL-c、hs-CRP及和肽素呈正相关(P<0.05),与HDL-c呈负相关(P<0.05)。结论:血浆和肽素与IL-18水平随着冠心病严重程度的增加而升高,其水平变化对冠心病的诊断、病情的严重程度、临床危险分层具有一定的临床意义。Objective： To explore the changes of hs-CRP,copeptin,IL-18 in coronary heart patients and its clinical significance.Methods： Subjects were divided into control group（n=36）,stable angina pectoris（SA） group（n=41）,unstable angina pectoris（UA） group（n=43） and acute myocardial infarction（AMI） group.The level of high-sensitivity C-reactive protein was detected by immune turbidimetry.Copetin was detected by immune nephelometry.The level of interleukin-18 was detected by enzyme-linked immunnosorbent assay（ELISA）.Results： Levels of WBC,NEU,hs-CRP,IL-18 and copeptin in SA group and control group were significantly higher than those in the control group（P 0.05）.Compared with UA group,the levels of hs-CRP,IL-18 were significantly increased in AMI group（P0.05）.The concentration of plasma IL-18 had a parallel relationship with TG,LDL-c,hs-CRP and copeptin（P0.01）,and a negative correlation with HDL-c.Conclusion： The levels of plasma IL-18,copeptin were elevated with the increase of disease severity and the detection of them may bring more instructive information in prognosis,disease severity assessment and risk stratification of coronary heart disease.

关 键 词：冠心病 和肽素 IL-18 炎症介质 

分 类 号：R541-4[医药卫生—心血管疾病]