幽门螺杆菌感染对儿童慢性特发性血小板减少性紫癜的相关性分析  

Relationship of Chronic Idiopathic Thrombocytopenic Purpura and Helicobactor Pylori in Children

作　　者：孙晓晗[1] 吕莹[1] 姜伟[1] 张秀秀[1] 陈霞[1] 

机构地区：[1]哈尔滨医科大学附属第二医院儿内科,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2012年第36期7080-7082,7115,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨幽门螺杆菌(H.pylori)感染和儿童慢性特发性血小板减少性紫癜(ITP)的相关性分析。方法:在2009至2011年,对360例健康儿童和360例慢性ITP患儿进行H.pylori感染检验,比较其H.pylori感染阳性率。将80例H.pylori感染阳性的慢性ITP患儿随机分为对照组和实验组各40人。对照组采用激素治疗,实验组采用抗幽门螺杆菌和激素联合治疗。结果:健康儿童H.pylori感染阳性40例,阳性率11.11%,慢性ITP患儿感染81例,阳性率22.5%。ITP患儿H.pylori感染阳性率高于健康儿童,2组H.pylori感染阳性率相比差异显著(P<0.05)。实验组患儿治疗后1、2、3个月的的血小板计数明显高于对照组,血小板相关免疫球蛋白低于对照组,差异显著(P<0.05)。实验组治疗总有效率高于对照组,差异显著(P<0.05)。实验组6个月内和6个月后的复发率均低于对照组,总复发率也低于对照组,差异显著(P<0.05)。结论:在慢性特发性血小板减少性紫癜患儿中幽门螺杆菌感染率要显著高于正常儿童,对慢性ITP患儿进行抗H.pylori感染治疗可以有效提高血小板计数,降低血小板相关免疫球蛋白,减少复发率,值得在临床上推广。Objective：To investigate the relationship of chronic idiopathic thrombocytopenic purpura and Helicobactor pylori in children.Methods：During 2009 to 2011 in our hospital,360 healthy children and 360 children with chronic ITP were tested with H.pylori infection Then compared their to compare H.pylori infection positive rate.80 cases of H.pylori infection in children with chronic ITP were randomly divided into two groups.Control group,including 40 cases were used hormone and test group including 40 cases used hormone and anti-Helicobacter pylori therapy.Results：Positive H.pylori infection rate of children with ITP was higher than that of healthy children,and the difference was statistically significant（P0.05）.PLT of test group was higher than control group and PAIgG of test group was lower than control group after treatment,and the difference was statistically significant（P0.05）.Total effective rate of test group was higher than control group,the difference was statistically significant（P0.05）.The recurrence rate of test group was lower than that of the control group,the difference was statistically significant（P0.05）.Conclusion：Positive H.pylori infection rate of children with ITP is higher than healthy children.To use anti-Helicobacter pylori therapy in chronic ITP children can effectively improve PLT count,cut down level of PAIgG and reduce recurrence rate.It can be popularized in clinical practice.

关 键 词：幽门螺杆菌 特发性血小板减少性紫癜 儿童 相关性 

分 类 号：R558[医药卫生—血液循环系统疾病] R725.5[医药卫生—内科学]