百癣夏塔热胶囊联合特比萘芬治疗趾甲真菌病46例的临床疗效  

The Clinical Effect of XTR Combined with Terbinafine in 46 Patients with Toenail Onychomycosis

作　　者：牟萍[1] 丁敏[1] 安徐生 李晶冰[1] 王艳[1] 

机构地区：[1]江苏省徐州市中心医院,江苏徐州221000

出　　处：《现代生物医学进展》2012年第36期7113-7115,共3页Progress in Modern Biomedicine

摘　　要：目的:分析百癣夏塔热胶囊联合特比萘芬治疗趾甲真菌病的临床疗效。方法:选择我院门诊就诊的趾甲真菌病患者92例。随机分为治疗组和对照组,治疗组:口服特比萘芬,250mg/次,1次/d,同时加服百癣夏塔热胶囊,2粒/次,3次/d;对照组:按治疗组相同方法服用特比萘芬。2组均以1个月为1个疗程,3个月结束作指标检测。12个月后随访趾甲真菌病的复发病情况。同时规定,患者每2周复诊1次,并记录安全性。观察期间所有受试者均不得使用其他对试验产生影响的药物或治疗方法。结果:治疗组46例中治愈34例,显效8例,有效6例,无效0例,治愈率73.91%,12个月后患者再次发病5例,复发率10.87%;对照组46例中治愈29例,显效8例,有效9例,无效0例,治愈率63.04%,12个月后患者再次发病15例,复发率32.60%。2组的治愈率和复发率比较差异显著(P<0.05)。不良反应:治疗组主要表现为消化道不适或腹泻,对照组主要表现为消化道不适,但不良反应都为短暂,不需任何处理,停药既恢复。结论:治疗组和对照组的治愈率和复发率比较,差异均显著(P<0.05),这对临床用药具有一定的指导作用。Objective：To evaluate the clinical effect of XTR combined with Terbinafine on toenail onychomycosis.Methods：92 patients who were diagnosed toenail onychomycosis in Xuzhou Central Hosputal were enrolled in the sudy.They were randomly divided into the trial group and the control group,the trail group：patients were receiving oral Terbinafine（250mg qd） and XTR（2 capsules tid）;the control group：patients were receiving oral Terbinafine（250 mg qd）.One month for a period of treatment.Related indexs were tested three months later and recurrence rate was followed up twelve months later.The agreement also stipulated that patients return visit every two weeks,keep a record of safety.And no drug or treatment should be used during the observation periods.Results：The trail group：Among the 46 cases,34 patients were clinically cured,8 markedly improved,6 effective.The cure rate was 73.91%;5 patients relapsed after 12months;the recurrence rate is 10.87%.The control group：Among the 46 cases,29 patients were clinically cured,8 markedly improved,9 effective.The cure rate was 63.04%;15 patients relapsed after 12months;the recurrence rate is 32.60%.Adverse reaction：Gastrointestinal tract reaction or diarrhea turned up in the trail group but only gastrointestinal tract reaction in the control group,all these adverse reactions were temporary,tended to resolve when the drugs were stopped.Conclusion：The cure rate and recurrence rate in treatment group was obviously better than those in control group（P 0.05）,showing the guiding function in instructing the clinical application.

关 键 词：趾甲真菌病 百癣夏塔热胶囊 特比萘芬 临床疗效 

分 类 号：R756.4[医药卫生—皮肤病学与性病学]