胰岛素泵强化治疗对初诊2型糖尿病的疗效观察  

The Therapeutic Effect of the Insulin Pump Intensive Therapy of Newly-Diagnosed Type 2 Diabetes Mellitus(T2DM) Patients

作　　者：曹丽华[1] 王力[1] 汪扬[1] 赵家慧[1] 德伟[2] 

机构地区：[1]南京市浦口区中心医院内分泌科,江苏南京211800 [2]南京医科大学生物化学与分子生物学系,江苏南京210029

出　　处：《现代生物医学进展》2012年第36期7116-7119,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(30670781)

摘　　要：目的:观察胰岛素泵强化治疗对合并肥胖和高脂血症的初诊2型糖尿病(T2DM)患者的疗效。方法:采用胰岛素泵持续皮下输注(CS‖)超短效门冬胰岛素(诺和锐)强化治疗15天(15d)54例合并肥胖和高脂血症的新诊断T2DM患者,分别在强化治疗15d结束时和继治疗90d时观察患者的血糖、糖化血红蛋白、血脂、体重指数和反应胰岛β细胞功能的胰岛素和C肽指标改变情况。结果:在强化治疗15d撤泵时和治疗90d后患者血糖明显下降;而糖化血红蛋白、血脂、体重指数、胰腺β细胞功能在治疗90d时改善明显。结论:早期胰岛素泵强化治疗新诊断的2型糖尿病(T2DM)患者,不仅可使其血糖尽早达标,而且还可明显降低血脂和体重指数、糖化血红蛋白,并使部分患者胰岛β细胞功能恢复,一段时期内脱离药物治疗,提高生活质量。Objective：To observe the therapeutic effect of the insulin pump intensive therapy of Newly-diagnosed type 2 diabetes mellitus（T2DM） patients merge with obesity and hyperlipidemia.Methods：The indices of blood sugar and glycated hemoglobin,blood Lipid,body mass index,insulin and c-peptide were observed respectively after 15 days of Insulin pump intensive treatment and after 90 days when the patients insulin pump was removed to.Results：The blood glucose decreased obviously in from pump and treat patients after 90 days.And glycated hemoglobin,blood Lipid,body mass index,pancreatic beta cells function got obviously better results after 90 days of treatment.Conclusion：Early insulin pump strengthening treatment of type 2 diabetes mellitus（T2DM） patients,not only can make its blood sugar standard as soon as possible,but also can obviously decrease the blood lipid and body mass index,and to make some cases with pancreatic beta cells function recovery,a period seprating theirself from drug therapy,improve life quality.

关 键 词：糖尿病 胰岛素泵 强化治疗 血糖 血脂 

分 类 号：R587.1[医药卫生—内分泌]