生物羊膜在鼓膜修补术中的应用价值研究  

Clinical Value of Biological Amnion in Myringoplasty

作　　者：李军政[1] 陈伟南[1] 张强[1] 田文栋[2] 

机构地区：[1]暨南大学医学院附属东莞医院耳鼻咽喉-头颈外科,广东东莞523000 [2]南方医科大学附属南方医院耳鼻咽喉-头颈外科,广东广州510515

出　　处：《现代生物医学进展》2012年第36期7150-7152,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81172053)

摘　　要：目的:探讨耳内镜下应用瑞济生物羊膜这一新型材料进行鼓膜修补术的可行性,为临床鼓膜修补术探索新的、更为理想的修复材料提供新的思路。方法:临床筛选18例(24耳)鼓膜紧张部中央性穿孔患者,在耳内镜下进行手术,修补材料应用瑞济生物羊膜作为移植材料,全部采用内植法行鼓膜修补术。移植材料内外均有明胶海绵支撑,术后10天取出外耳道填塞物。结果:术后随访6个月,除2例(2耳)术后感染而穿孔未愈外,其余16例(22耳)全部一期愈合,鼓膜形态完好,无手术并发症发生,成功率97.1%。结论:内镜下经外耳道鼓膜成形术具有创伤小、术后恢复快、疗效好的优点。瑞济生物羊膜来自同种异体,成分单一,抗原少,免疫排斥小,可规模化、标准化生产,手术应用操作简单方便,成功率高,可作为鼓膜修补术较为理想的移植修复材料,值得临床推广应用。Objective：To evaluate the success rate and feasibility of human biological amnion in myringoplasty and find new and more ideal repair materials for myringoplasty.Methods：Eighteen consecutive patients with persistent tympanic membrane perforation were included in this study.All patients underwent graft myringoplasty using human biological amnion.inside and outside of graft materials all have supported by gelatin sponges.After 10 days the wadding have been taken out of external auditory canal.Treatment success was defined as an intact tympanic membrane（TM） at the 6-month follow-up visit.Results：After a follow up of 6 months,all were healed except two induced by bacteria infection.Tympanic membrane growth in good condition.Closure of tympanic membrane perforations with this new repair materials was achieved in 22 out of the 24 ears,with a success rate of 97.1%.Conclusion：Endoscopic transcanal myringoplasty had advantages of minimal invasion,quick recovery,and excellent curative effects.Human biological amnion,a new transplantation material for myringoplasty,was worth to be popularized in clinc because it was easy to obtain and operate and Scale,standardized produce.

关 键 词：耳内境 生物羊膜 鼓膜穿孔 鼓膜修补术 

分 类 号：R764.92[医药卫生—耳鼻咽喉科]