焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响(英文)  

Influence of anxiety or depression on prethrombotic state in patientswith essential hypertension

作　　者：孔德贵[1] 路玉桥[1] 祁学文[1] 马龙乐[1] 孔祥泉[1] 

机构地区：[1]聊城市人民医院心内科,山东聊城252000

出　　处：《心血管康复医学杂志》2013年第1期14-18,共5页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察焦虑或抑郁情绪对原发性高血压患者血栓前状态的影响。方法:112高血压病患者被均分为高血压合并焦虑或抑郁组(EH+A/D组)和单纯高血压组(EH组),测定两组病人血清CD62P、血管假性血友病因子(vWF)、组织型纤溶酶原激活剂(t-PA)、组织型纤溶酶原激活剂抑制剂(PAI-1)、内皮素(ET)-1等血栓前状态指标水平。结果:与EH组比较,EH+A/D组CD62P[(4.52±2.01)%比(8.38±1.96)%]、vWF[(155.28±23.11)%比(185.23±22.21)%]、PAI-1[(54.35±13.21)ng/L比(79.88±14.53)ng/L]、ET-1[(121.56±33.32)ng/L比(152.78±30.23)ng/L]水平明显升高(P均<0.05),而t-PA[(19.37±11.46)ng/L比(9.56±8.32)ng/L]水平明显降低(P<0.05)。结论:焦虑或抑郁情绪会通过激活血小板、影响血管内皮功能及纤溶系统的失衡,加重原发性高血压患者血栓前状态。Objective： To observe influence of anxiety or depression on prethrombotic state in patients with essential hypertension （EH）. Methods： A total of 112 EH patients were equally divided into EH＋A/D group and pure EH group. Levels of prethrombotic state indicators, including serum CD62P, von Willebrand factor （vWF）, tissue type plasminogen activator （t-PA）, plasminogen activator inhibitor （PAD -1 and endothelin （ET） -1 were measured in two groups. Results： Compared with pure EH group, there were significant increase in levels of CD62P [ （4. 52＋ 2.01） % vs. （8. 384-1.96） %], vWF [（155. 28±23.11） % vs. （185.23±22.21） %], PAI-1 [（54.35±13.21） ng/ L vs. （79.88±14.53） ng/L] and ET-1 [（121.56＋33.32） ng/L vs. （152.78±30.23） ng/L], P〈0.05 all; and sig- nificant decrease in t-PA level [（19. 37±1.46） ng/L vs. （9. 56±8.32） ng/L, P〈0.05] in EH4-A/D group. Con- clusion： Anxiety or depression can aggravate prethrombotic state of patients with essential hypertension through ac- tivation of platelets, influencing vascular endothelial function and fibrinolytic system imbalance.

关 键 词：焦虑 抑郁 高血压 

分 类 号：R544.109[医药卫生—心血管疾病]