电针丰隆穴对高脂血症大鼠巨噬细胞ICAM-1、MCP-1含量的影响  

Effect of electroacupuncture at "Fenglong"(ST40) on ICAM-1 and MCP-1 in macrophages of rats with hyperlipidemia

作　　者：乐薇[1] 肖颖[1] 黄浩[2] 周利[2] 田佳玉[1] 陈盈芳[1] 

机构地区：[1]湖北中医药大学针灸骨伤学院,武汉430065 [2]武汉市中西医结合医院,武汉430022

出　　处：《中国康复》2013年第1期3-5,共3页Chinese Journal of Rehabilitation

基　　金：武汉市卫生局科研项目[武卫(2011)99号]

摘　　要：目的:观察电针丰隆穴对高脂血症大鼠炎症因子细胞间粘附分子(ICAM-1)、单核细胞趋化因子(MCP-1)含量的影响。方法:SD大鼠50只,随机分为空白对照组(A组)、模型对照组(B组)、模型饮控组(C组)、模型电针组(D组)、模型饮控+电针组(E组)各10只。干预60d后,测定血脂含量及ICAM-1、MCP-1的含量。结果:与A组比较,B组大鼠血浆胆固醇(TC)、低密度脂蛋白(LDL-C)含量明显上升(均P<0.01),高密度脂蛋白(HDL-C)明显下降(均P<0.01);C、D组大鼠血浆TC、LDL-C与B组比较均明显下降(P<0.05,0.01),但较A组均明显升高(均P<0.01);E组大鼠血浆中TC、LDL-C含量均较B、C组明显降低(均P<0.01)。除E组外,其余各组大鼠腹腔巨噬细胞及ICAM-1、MCP-1含量与A组比较均明显增加(P<0.05,0.01),且B、C组增加更为显著(均P<0.01);与B、C组比较,E组巨噬细胞及ICAM-1、MCP-1含量显著下降(均P<0.01)。结论:电针丰隆穴能够明显下调高脂血症大鼠血浆中的TC、LDL-C、巨噬细胞及ICAM、MCP-1的含量,从而达到对高脂血症的治疗作用。Objective：To study the effect of electroacupuncture at the ＂Fenglong＂ on inflammatory factors ICAM1 and MCP1 of rats with hyperlipemia （HLP）. Methods：Fifty health male SD rats were randomly divided into 5 groups： normal control group （A）, model control group （B）, model -- normal diet group （ C）, model ＋electroacupuncture group （D）, model＋normal diet@electroacupuncture group （E） （n=10 each group）. After intervention for 60 days,blood fat and the expression of ICAM-1 and MCP-1 were detected. Results：As compared with group A,the contents of TC and LDL-C were significantly increased and HDL-C significantly reduced in group B（P〈0.05,0. 01）. The contents of TC and LDL-C were significantly decreased in groups C and D as compared with group B, and those in groupsB, C, D were significantly higher than in group A （all P〈0.01）. As compared with groups B and C, the contents of TC and LDLC were significantly redeuced in group E（ all P〈0.01）. The number of macrophages, the expression levels of ICAM-1 and MCP-1 in groups B, C, D were obviously increased as compared with group A（P〈0.05,0. 01 ）, more significantly in groups B and C（all P〈0.01）. The number of macrophages, and the expression levels of ICAM-1 and MCP-1 in group E were obviously decreased as compared with group B and C（all P〈0.01）. Conclusion： Electroaeupuncture at ＂Fenglong＂ can notably decrease the contents of TC and LDI.-C,the number of macrophages, and the expression levels of ICAM-1 and MCP-1, thereby have therapeutical effect on hyperlipemia.

关 键 词：电针 丰隆穴 高脂血症 巨噬细胞 胞间粘附分子-1 单核细胞趋化蛋白-1 

分 类 号：R245[医药卫生—针灸推拿学]