应用乌司他丁治疗严重多发伤血清IL-6、IL-8、IL-10、TNF-α的表达及临床意义  

The expression and clinical significance of IL-6、IL-8 、IL-10 and TNF-α in severe multiple injuries after Ulinastatin treatment

作　　者：陈宁波[1] 曾杰[1] 李艳[1] 张健[1] 陈仿[1] 刘建[1] 胡卫建[1] 

机构地区：[1]四川省人民医院急救中心外科,四川成都610072

出　　处：《四川医学》2013年第1期1-4,共4页Sichuan Medical Journal

基　　金：四川省卫生厅科研项目(编号:090484)

摘　　要：目的探讨应用乌司他丁治疗严重多发伤血清IL-6、IL-8、IL-10、TNF-α的表达及临床意义。方法选取我院就诊的严重多发伤患者80例,分为治疗组40例(应用乌司他丁治疗)和对照组40例(未用乌司他丁治疗)。分别于发病就诊后第0.5、1、2、3、5、7d静脉取血,测定两组血清IL-6、IL-8、IL-10、TNF-α的变化,比较二者之间的差异。结果多发伤患者IL-6、IL-8、IL-10、TNF-α的含量在伤后即升高,第1～3天达峰值后开始下降。IL-6、IL-8、TNF-α的含量在应用乌司他丁治疗后在早期时段均低于对照组,差异有统计学意义(P<0.01)。乌司他丁能促进抗炎因子IL-10的产生,与对照组差异有统计学意义(P<0.01)。结论乌司他丁早期即能降低促炎因子IL-6、IL-8、TNF-α的产生和促进抗炎因子IL-10的产生,抑制多发伤患者的炎症反应,提高其抢救成功率。Objective To investigate the expression and clinical significance of 1L- 6,1L- 8 ,IL-10 and TNF-α in severe multiple injuries after Ulinastatin treatment. Methods 80 cases of severe multiple injuries were divided into treatment group （40 cases with Ulinastatin treatment） and control group （40 cases with no Ulinastatin treatment）. The level of 1L- 6 ,IL- 8, IL-10 and TNF-α in veno-blood serum were detected when the O. 5,1,2,3,5,7 days after trauma, Compare the difference between the two groups. Results The level of 1L- 6,1L- 8, IL-10 and TNF-α increased immediately after trauma, and the peak value was a- chieved at 1 ～3days. The level of these eytokines in treatment group were lower than those in control group at prophase, there was statistical significance in two groups （P 〈0. 01 ）. Ulinastatin can promote the level of anti-inflammatory IL-10 at prophase, there was statistical significance in two groups（P 〈0. 01 ）. Conclusion Ulinastatin can reduce the the level of IL- 6 ,IL- 8 ,and TNF-α （proinflammatory factor）, but it can promote the level of 1L-10 （anti-inflammatory factor）. Ulinastatin can inhibit the inflammatory reaction of severe multiple injuries and improve the achievement ratio.

关 键 词：乌司他丁 多发伤 细胞因子 

分 类 号：R641[医药卫生—外科学]