暂时性肝门阻断时门体分流对大鼠肝脏能量代谢的影响  

The Protection effect for energy metabolism of temporary portocaval shunt for the ischemia reperfusion injury in rats liver

作　　者：翁敏[1] 骆助林[1] 曾维政[1] 汪涛[1] 田伏洲[1] 戴睿武[1] 黄竹[1] 程龙[1] 王华[1] 

机构地区：[1]成都军区总医院消化内科普通外科,四川成都610083

出　　处：《四川医学》2013年第1期4-6,共3页Sichuan Medical Journal

基　　金：全军"十一五"重大专项课题(编号:08Z012)

摘　　要：目的比较暂时性肝门阻断时,门静脉分流和阻断对大鼠缺血再灌注后肝脏能量代谢的影响,为临床上减轻肝缺血再灌注损伤选取手术方式提供参考。方法将大鼠分为假手术组、实验组和对照组3组,制作门颈静脉转流下大鼠肝脏缺血再灌注模型,观察大鼠术后1h、6h、24h、3d及7d肝脏能量代谢变化。结果①术后各时相点对照组RCR值和P/O均显著低于实验组,恢复正常时间对照组也晚于实验组;②实验组于术后各相应时相点肝细胞ATP含量均高于对照组,并且恢复正常也比对照组较早。结论暂时性肝门阻断时门体分流处理能够改善能量代谢,提高缺血再灌注后肝脏的抗损伤能力。Objective A model of ischemia reperfusion injury of rat liver with portal-cervical bypass established in this experiment to compare different effect on rats energy metabolism between the group of portal-cervical bypass and that of interruption of portal vein, which provides a reference for clinical operation manner to reduce ischemia rePerfusion injury in liver surgery. Methods A model of iscbemia reperfusion injury of rat liver with portal-cervical bypass established in this experiment to compare different effect on rats energy metabolism between the group of portal-cervical bypass and that of interruption of portal vein. Re- stilts The high ATP concentration, RCR and P/O at each corresPonding time-Point, and shorter recovery time in bypass group than that in interrupted group was found in this experiment. Conclusion The current results show that employing portocaval shunt method may improve energy metabolism of rat liver after operation.

关 键 词：缺血再灌注损伤 动物模型 门体分流 能量代谢 

分 类 号：R657.3[医药卫生—外科学]