2430例新生儿高胆红素血症血培养及药敏分析  

Analysis of the blood germiculture and microbial sensitivity tests in 2430 neonatal hyperbilirubinemia cases

作　　者：王模奎[1] 黄薇[1] 宗小敏[1] 苏华英[1] 杨介梅[1] 罗代辉[1] 王琴[1] 吕勇彬[1] 肖亚雄[1] 

机构地区：[1]宜宾市第一人民医院新生儿科检验科,四川宜宾644000

出　　处：《四川医学》2013年第1期157-159,共3页Sichuan Medical Journal

摘　　要：目的探讨宜宾市新生儿高胆红素血症患儿的病原菌及药物敏感性情况,以便为临床合理用药提供依据。方法回顾分析2430例新生儿高胆红素血症患儿血培养及体外抗菌药物敏感性试验结果。结果在2430例新生儿高胆红素血症患儿血培养中,290例细菌培养阳性,阳性率为11.9%;其中革兰阳性菌246株(84.8%),革兰阴性菌44株(15.2%)。表皮葡萄球菌显著多于溶血葡萄球菌(=16.6,P<0.01)。表皮葡萄球菌对万古霉素和夫西地酸的敏感率分别达100%和94.8%,对苯唑西林耐药率达62.9%。溶血葡萄球菌对万古霉素和夫西地酸的敏感率分别达96.3%和94.4%;对苯唑西林耐药率达74.1%。溶血葡萄球菌对红霉素的耐药性显著高于表皮葡萄球菌(=4.98,P<0.05)。结论葡萄球菌属细菌为本地区新生儿高胆红素血症患儿的主要病原菌,推荐首选多肽类抗菌药或夫西地酸,不建议首选青霉素类、头孢菌素类和大环内酯类抗菌素。Objective To investigate the pathogen and its＇ s susceptibility to anti-bacterial agents that of the neonates suf- fered from neonatal hyperbilirubinemia in our hospital, so as to provide some basis reference to clinical doctor for reasonable use of anti-bacterial agents. Methods Retrospective analysis the blood germicuhure and microbial sensitivity tests results that of neo- natal hyperbilirubinemia in 2430 cases. Results Among the 2430 cases＇ blood germicuhure,290 positive cases, positive rates was 11.9% ; 246 strains Gram-positive bacteria （84. 8% ） and 44 strains Gram-negative bacteria （ 15.2% ）. Staphylococcus epi- dermidis were significant more than staphylococcus haemolyticus（ X2 = 16. 6, P 〈0. 01 ）. The susceptible percentages to anti-bac- terial agents of staphylococcus epidermidis for vancocin and fusidic acid were 100% and 94. 8%, respectively, for oxacillin, tile resistant percentage was 62. 9%. Meanwhile, the susceptible percentages of Staphylococcus haemolyticus for vancocin and fusidic acid were 96. 3% and 94. 4%, respectively ; for oxacillin, the resistant percentage was 7/4. 1%. Staphylococcus haemolyticus were significant resistant to erythrocin than staphylococcus epidermidis （X2= 4. 98, P 〈 0. 05 ）. Conclusion Staphylococcus are the main pathogen in local neonatal hyperbiliruhinemia. Not penicillins, eephalosporins and macrolides, hut polypeptides anti-bacteri- al agents or fusidie acid should be recommend first.

关 键 词：新生儿 高胆红素血症 病原菌 微生物敏感试验 抗菌素 

分 类 号：R446.5[医药卫生—诊断学]