159例药品不良反应/事件报告分析  

Adverse Drug Reactions/Events:Analysis of 159 Cases

作　　者：陈芳[1] 

机构地区：[1]南京医科大学附属苏州医院药剂科,江苏苏州215001

出　　处：《中国医院用药评价与分析》2012年第11期1028-1030,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:通过对159例药品不良反应/事件报告的系统分析,探讨南京医科大学附属苏州医院药品不良反应/事件的特点,从而开展药物警戒,为临床合理用药提供依据。方法:采用回顾性研究方法,对2010年我院上报的药品不良反应/事件报告进行系统分析。结果:在159例药品不良反应/事件报告中,静脉给药发生最多(123例,占77.4%),≥60岁的老年人发生率高于其他年龄段(46例,占28.9%),有关抗菌药物的报告最多(108例,占67.9%)。严重的不良反应/事件为7例(占4.4%),相关药物为注射用头孢西丁钠、注射用奥沙利铂、胺碘酮片、注射用克林霉素、注射用头孢吡肟、注射用头孢唑肟。结论:应重视药品不良反应/事件,提高合理用药水平,以减少和避免药品不良反应/事件,保障公众用药安全。OBJECTIVE：To analyze the characteristics of the adverse drug reactions/events（ADR/ADE） through systemic analysis on a total of 159 ADR/ADE cases collected in Suzhou Hospital Affiliated to Nanjing Medical University so as to improve pharmacovigilance and provide reference for clinical rational drug use.METHODS：By a retrospective study,a total of 159 ADR/ADE reports collected by Suzhou Hospital of Nanjing Medical University from January to December in 2010 were analyzed systematically.RESULTS：Of the total 159 ADR/ADE cases,123 cases（77.4%） were induced by intravenous route of administration,with elder patients who ≥60 years showing higher proportion（46 cases,27.5%）;108 cases（68.8%） were induced by antibiotics;7（4.4%） were regarded as serious cases.The drugs involved in ADR/ADE included Cefoxitin Sodium for injection,Oxaliplatin for injection,Amiodarone tablets,Clindamycin for injection,Cefepime for injection,and Ceftizoxime for injection.CONCLUSION：Great importance should be attached to the reporting and monitoring on ADR/ADE and rational use of drugs in order to avoid or reduce the occurrence of ADRs/ADEs and ensure public medication safety.

关 键 词：药品不良反应 事件 统计 监测 分析 

分 类 号：R969.3[医药卫生—药理学]