宁德市医院专项整治活动前后抗菌药物应用分析  

Clinical Use of Antibacterials in Ningde Municipal Hospital Before and After Special Rectification:A Contrastive Analysis

作　　者：许江涛[1] 陈子春[1] 林敏华[1] 阮月惠[2] 

机构地区：[1]福建医科大学教学医院宁德市医院临床药学室,福建宁德352100 [2]福建医科大学药学院,福州350004

出　　处：《中国医院用药评价与分析》2012年第12期1096-1100,共5页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:调查宁德市医院2011年专项整治活动前后抗菌药物的临床应用情况,总结经验,找出存在的问题,为抗菌药物的合理应用和管理提供依据。方法:采用回顾性调查法,分别抽取专项整治前(2011年1—6月)与整治后(2011年7—12月)Ⅰ类切口手术病例173、187例,对所应用抗菌药物品种、销售金额、用药频度(DDDs)、使用率及Ⅰ类切口手术预防用药指标等进行统计分析。结果:专项整治活动后应用抗菌药物品种数由68种调整至50种;抗菌药物销售金额占药品总销售金额的百分比由16.52%降至13.27%;抗菌药物DDDs较整治前下降了9.87%;病房用药结构变化较大,第2、3代头孢菌素的DDDs较整治前增长,而β-内酰胺+β-内酰胺酶抑制剂复方制剂的DDDs则明显下降;抗菌药物使用率和使用强度等临床用药指标均较整治前改善;Ⅰ类切口手术抗菌药物预防性使用率、用药时间从整治前的80.35%、(1.90±0.92)d,分别下降至59.36%、(1.53±0.76)d,差异具有统计学意义。结论:我院抗菌药物专项整治初显成效,但少数用药指标与卫生部整治活动的目标仍有差距,需进一步提高合理用药水平。OBJECTIVE：To investigate the clinical use of antibacterials in Ningde Municipal Hospital in 2011 before and after special rectification on clinical application of antibacterial drugs in order to gather experience,find out the problems and provide references for rational application and management of antibacterials.METHODS：Using retrospective analysis,173 surgical cases of typeⅠincision before rectification（during January-June period of 2011） and another 187 surgical cases of typeⅠincision after rectification（during July-December period of 2011） were collected for statistical analysis with regard to variety of antibacterials,consumption sum,DDDs,rate of antibiotic use and indicators for prophylactic use of antibiotics in type I incision surgical cases etc.RESULTS：After rectification as compared with before rectification,the number of antibacterials decreased from 68 to 50;the proportion of antibacterials in the total drugs decreased from 16.52% to 13.27% in terms of consumption sum,with DDDs dropped 9.87%;the utilization structure of antibacterials witnessed a great change in that the DDDs of second and third generations cephalosporin increased,while that of compound preparation of Beta-Lactam and beta-lactamase inhibitors decreased significantly;the rate of antibiotic use and the antibiotic use density（AUD） and other clinical antibiotic use indicators all improved after rectification;the rate of antibiotic use and the number of days of antibiotic use in typeⅠincision surgical cases dropped from 80.35% and（1.90±0.92） days to 59.36% and（1.53±0.76） days,showing statistical significance.CONCLUSION：The special rectification on antibacterials carried out in our hospital has achieved effectiveness;however,there is long way to go before meeting the goal of the Ministry of Health on special rectification of antibacterials,and the rationality of antibiotic use remains to be improved further.

关 键 词：抗菌药物 专项整治 合理用药 

分 类 号：R978.1[医药卫生—药品]