一种强化戊二醛消毒剂相关性能的试验观察  

EXPERIMENTAL OBSERVATION ON RELATED PROPERTIES OF A POTENTIATED GLUTARALDEHYDE DISINFECTANT

作　　者：韩坤[1] 张术斌[1] 曾家慧[1] 付大仁[1] 

机构地区：[1]宁夏回族自治区疾病预防控制中心,银川750004

出　　处：《中国消毒学杂志》2013年第1期15-17,共3页Chinese Journal of Disinfection

摘　　要：目的观察一种强化戊二醛消毒剂杀菌效果与使用安全性,为实际应用提供参考。方法采用理化分析和载体定量杀菌试验方法,对该戊二醛消毒剂的相关性能进行实验室试验。结果该戊二醛消毒剂由20 g/L戊二醛与某非离子表面活性剂以及其他辅助成分组成,其原液pH值为6.77,54℃条件下存放14 d,戊二醛含量下降率3.86%。以戊二醛浓度为20 g/L的该消毒剂对载体上枯草杆菌黑色变种芽孢作用60 min,平均杀灭对数值>3.0。戊二醛消毒液pH值降低对其杀菌效果有严重影响。该戊二醛消毒液对小鼠经口急性毒性LD50值>5 000 mg/kg(体重),对小鼠嗜多然红细胞微核试验结果阴性。结论试验表明,该强化戊二醛消毒剂对细菌芽孢具有良好的杀灭效果,属于实际无毒,无致微核作用,性能稳定。Objective To observe the germicidal effect and safety usage of glutaraldehyde disinfectant, in order to pro- vide reference for the actual use. Method Physical - chemical analysis and carrier quantitative germicidal test were used to test the related properties of glutaraldehyde in laboratory. Results The glutaraldehyde disinfectant consisted of 20 g/L glutaraldehyde and non - ionic surfactant and other helper constituents. The pH value was 6. 77. Its content decreased by 3.86% after storing at 54℃ for 14 days. The carrier quantitative germicidal test showed that the killing logarithm of Bacil- lus subtilis vas. niger spore exposed to the solution for 60 mins was 〉 3.0. The pH value decline of solution had serious in- fluence on killing effect. The LDso of white mouse acute toxicity test was 〉 5 000 mg/kg . w . Mouse bone marrow poly- chromatic erythrocyte micronucleus test was negative. Conclusion The experiment showed that the germicidal function of potentiated glutaraldehyde disinfectant had good germicidal effect which was innocuous and had no effect of micronucleus and had stable function.

关 键 词：戊二醛 消毒剂 枯草杆菌黑色变种 杀菌效果 毒性 

分 类 号：R187.1[医药卫生—流行病学]