剑花提取物的止咳祛痰平喘作用研究  

Antitussive,apophlegmatic,and anti-asthmatic effects of extract from Hylocerei Undati Flos

作　　者：付书婕[1] 黄兴振[1] 巫玲玲[1] 龙凤鸣 韦秀芝 蒋伟哲[1] 

机构地区：[1]广西医科大学,广西南宁530021 [2]河池市第一人民医院,广西河池546300

出　　处：《药物评价研究》2013年第1期18-21,共4页Drug Evaluation Research

基　　金：广西自然科学基金项目(桂科自0991264)

摘　　要：目的探讨剑花提取物的止咳、祛痰、平喘功效。方法通过动物模型引咳、祛痰和引喘实验研究剑花止咳、祛痰、平喘效果。实验分为对照组,剑花提取物低、中、高剂量组及阳性药组。结果与对照组比较,高、中、低剂量的2种剑花提取物均能显著减少浓氨水所致小鼠咳嗽次数(P<0.05、0.01);剑花水提物和剑花醇提物中、高剂量组能明显增加小鼠呼吸道的酚红排泄量(P<0.05、0.01);剑花水提物和剑花醇提物高剂量组能显著延长枸橼酸所致豚鼠的哮喘潜伏期(P<0.05)。结论剑花提取物具有明显的止咳、祛痰、平喘作用。Objective To study the antitussive,apophlegmatic,and anti-asthmatic effects of the extract from Hylocerei Undati Flos（EHUF）.Methods The antitussive,apophlegmatic,and anti-asthmatic effects of EHUF were observed using cough-inducing,eliminating phlegm,and asthma-inducing mouse models.Normal mice were randomly divided into control,positive control,low-,mid-,and high-dose EHUF groups.Results Compared with the control group,high-,mid-,and low-dose of two types of EHUF could decrease the cough rate significantly in mice induced by ammonia solution（P 0.05,0.01）;Aqueous EHUF and alcohol EHUF in mid-and high-dose could increase the excretion of phenolsulfonphthalein significantly in the respiratory tract of mice（P 0.05,0.01）;Aqueous EHUF and alcohol EHUF in high-dose could also prolong the asthma latency period resulted from citric acid in guinea pigs significantly（P 0.05）.Conclusion The EHUF has significant antitussive,apophlegmatic,and anti-asthmatic effects.

关 键 词：剑花提取物 药效 止咳 祛痰 平喘 

分 类 号：R974[医药卫生—药品]