危重症患儿整合素α4β7和L-选择素水平变化及其意义探讨  

The changes and significance of integrin α4β7 and L-selectin levels in critical children

作　　者：陈永前[1] 王爱华[1] 武艳红[1] 朱保权[1] 

机构地区：[1]兰州大学第二医院儿科,730030

出　　处：《中国医师进修杂志》2013年第4期3-5,共3页Chinese Journal of Postgraduates of Medicine

基　　金：甘肃省科技厅科学事业经费资助项目（0709TCYA061）

摘　　要：目的探讨危重症患儿胃肠功能衰竭时整合素α4β7及L-选择素的表达及其与肠道黏膜免疫功能的关系。方法选择危重症患儿48例，按有无胃肠功能衰竭分为非胃肠功能衰竭组（29例）及胃肠功能衰竭组（19例），另选择同期25例健康体检儿童作为对照组。应用流式细胞仪检测各组整合素α4β7和L-选择素的表达，并进行比较。结果胃肠功能衰竭组整合素α4β7[（11．11±1．15）％]显著低于非胃肠功能衰竭组[（15．36±1．26）％]和对照组[（19．62±0．89）％]（P〈0．05），非胃肠功能衰竭组整合素α4β7与对照组比较差异无统计学意义（P〉0．05）。胃肠功能衰竭组L．选择素[（60．68±3．72）％]显著低于非胃肠功能衰竭组[（69．43±1．52）％]和对照组[（88．65±2．41）％]，非胃肠功能衰竭组L选择素显著低于对照组，差异均有统计学意义（P〈0．05）。结论整合素α4β7和L-选择素水平在危重症患儿发生胃肠功能衰竭的早期开始降低，且整合素α4β7在胃肠功能衰竭时降低更加明显。Objective To explore the changes of integrin α4β7 and L-selectin levels and the possible relationship between the changes and intestinal mucosal immune function in critical children with gastrointestinal dysfunction. Methods Forty-eight admitted critical children were divided into non-gastrointestinal dysfunction group （29 cases ） and gastrointestinal dysfunction group （ 19 cases）, and also compared with 25 healthy people （control group）. The expression of integrin α4β7 and L-selectin was measured by flow cytometry. Results The expression of integrin α4β7 in gastrointestinal dysfunction group[ （ 11.11 ± 1.15 ）% ] was lower than that in non-gastrointestinal dysfunction group [ （ 15.36 ± 1.26）% ] and control group [（19.62 ±0.89）% ] （P 〈0.05）, but there was no significant difference between non- gastrointestinal dysfunction group and control group（P 〉 0.05）. The expression of L-selectin in gastrointestinal dysfunction group [（60.68 ±3.72）% ] was lower than that in non-gastrointestinal dysfunction group [ （69.43 ± 1.52）% ] and control group [ （88.65 ± 2.41 ）% ] （P 〈 0.05 ）, and there was significant difference between non-gastrointestinal dysfunction group and control group （P 〈 0.05）. Conclusion The expression of integrin α4β7 and L-selectin is decreased at the early stage of gastrointestinal dysfunction in critical childern, and integrin α4β7 is decreased sharply.

关 键 词：危重病 L选择素 胃肠功能衰竭 整合素α4β7 

分 类 号：R459.7[医药卫生—急诊医学]