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机构地区:[1]华中科技大学同济医学院附属同济医院,武汉430030
出 处:《微循环学杂志》2013年第1期49-52,I0002,共5页Chinese Journal of Microcirculation
摘 要:目的:观察益气通阳化痰方联合西洛他唑治疗下肢动脉硬化性闭塞症(ASO)的临床疗效。方法:选择ASO患者90例,随机分为中药治疗组、西药治疗组和中西药治疗组(n均=30)。治疗8周后,观察患者临床疗效,比较治疗前后患肢动脉狭窄程度及踝/肱指数(ABI)、最大行走距离、患肢血流参数、甲襞微循环积分、血液流变学指标的变化。结果:中药治疗组、西药治疗组和中西药治疗组的临床总有效率分别为80.00%、83.33%、93.33%。治疗前三组ABI、最大行走距离、下肢血流参数、甲襞微循环积分、血液流变学指标无显著性差异(P>0.05);治疗8周末,三组上述指标较治疗前显著改善(P<0.05),中西药治疗组更优于中药治疗组和西药治疗组(P<0.05),而中药治疗组与西药治疗组比较无显著性差异(P>0.05)。结论:益气通阳化痰方联合西洛他唑治疗ASO具有较好疗效。Objective: To observe the effects of Yiqitongyanghuatan decoction (YQTYHTD) and cilostazol in the treatment of arteriosclerostic occlusive disease (ASO) in lower limbs. Method: Ninety patients with ASO in lower limbs were divided randomly into three groups: TCM group (treated with Yiqitongyanghuatan decoction only), WM group (treated with cilostazol only), TCM-WM group (treated with both Yiqitongyanghuatan decoction and cilostazol).The course of treatment was eight weeks. Before and after the treatment, the changes of symptoms, microcirculation integral, the main items of hemorheology, the vascular diameters, and peak blood velocity of the lower limbs were detected. Results: The clinical effective rate of TCM group, WM group and TCM-WM group was 80.00%,83.33% and 93.33%. The symptoms,microcirculation integral and main items of hemorheology were not significant different in three groups before treatment(P>0.05).Obvious improvement was found after treatment(P<0.05). TCM-WM group was better than TCM group and WM group(P<0.05). There was no significant difference in TCM group and WM group(P>0.05). Conclusion: Combination of Yiqitongyanghuatan decoction and cilosrazol is effective in the treatment of arteriosclerostic occlusive disease.
分 类 号:R543.5[医药卫生—心血管疾病]
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