瘦素、IL-6水平与慢性阻塞性肺疾病患者病情的关系  

Relationship between the eptin,IL-6 level and the progression of chronic obstructive pulmonary disease

作　　者：蔡志芳[1] 姚汉玲[1] 周胜兰[1] 

机构地区：[1]湖北省武汉市汉口医院呼吸内科,湖北武汉430012

出　　处：《海南医学院学报》2013年第2期183-185,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210511)~~

摘　　要：目的:探讨瘦素、白细胞介素-6(IL-6)水平与慢性阻塞性肺疾病患者病情严重程度的关系。方法:选取我科收治的36例急性加重期患者及40例临床缓解期患者,分别检测两组患者血清瘦素、IL-6水平,其中对急性加重期患者测两次,分别为治疗前及治疗2周后,并对两组患者血气指标进行监测比较,对急性加重期患者血清瘦素水平与其血气指标进行相关性分析。结果:急性加重期患者治疗前血清瘦素及IL-6水平明显高于临床缓解期患者(P<0.05),治疗后血清瘦素及IL-6水平与临床缓解期患者比较无显著差异(P>0.05)。急性加重期患者治疗前PaCO2明显高于临床缓解期患者,PaO2及SaO2明显低于临床缓解期患者(P<0.05),两组患者治疗后各血气指标无显著差异(P>0.05)。急性加重期患者血清瘦素水平与PaCO2呈正相关,与PaO2及SaO2呈负相关。结论:慢性阻塞性肺疾病患者急性加重期时血清瘦素和IL-6水平明显增高,这两种因子可能与疾病的发生和发展相关,临床上通过检测其水平可判断病情严重程度,并可作为反映全身炎症反应程度的重要指标。Objective： To study the relationship between leptin, IL-6 level and severity of chronic obstructive pulmonary disease （COPD）. Methods. Selected 36 cases of acute aggravation phase of COPD （group A） and 40 patients with clinical remission stage of COPD （group B） that were treated in our de- partment. Serum leptin, IL-6 levels were detected in both groups, but were measured twice in group A, which were conducted before treatment and 2 week after treatment separately. Blood ＇gas indexes were compared between the two groups, and correlation between serum leptin level and blood gas indexes were compared. Results. Serum leptin and IL-6 levels of group A was significant higher than that of group B, but after treatment, the difference was not observed anymore. Before treatment, PaCO2 of group A wassignificant higher than that of group B （P^0.05）, but PaO2 and SaO2 were lower. After treatment, no significant differences in blood gas indexed were found between the two groups. During acute aggravation stage of COPD, serum leptin was negatively correlated with PaCO2 level, but negatively correlated with PaO2 and SaO2. Conclusion. During acute aggravation stage of COPD, serum leptin and IL-6 levels in- creased significantly, indicating they were correlated with the occurrence and progression of the diseases, and can be used as indicators for severity of COPD and the systemic inflammatory response

关 键 词：慢性阻塞性肺疾病 瘦素 白介素-6(IL-6) 

分 类 号：R563[医药卫生—呼吸系统]