急性肺损伤患者肺损伤评分与AGEs在预后评价中的作用  

Value of lung injury score and AGEs in prognostic of patients with acute lung injury

作　　者：蔡兴俊[1] 黄奕江[1] 付姣[1] 莫濡冰[1] 

机构地区：[1]海南省人民医院呼吸内科,海南海口570311

出　　处：《海南医学院学报》2013年第2期186-188,共3页Journal of Hainan Medical University

基　　金：海南省卫生厅科学研究课题(琼卫2009-18)~~

摘　　要：目的:探讨联合应用肺损伤评分(LIS)及晚期糖基化终末产物(AGEs)在预测急性肺损伤患者转归的作用。方法:采用酶联免疫吸附法(ELISA法)测定30例ALI患者血浆AGEs浓度,同时进行肺损伤评分(LIS);根据转归情况将ALI患者分为死亡组(8例)和生存组(22例),结合AGEs、LIS对两组进行比较分析。结果:死亡组与生存组血浆AGEs及LIS评分比较差异有统计学意义(P<0.05);AGEs与LIS评分呈显著正相关(r=0.926,P<0.01)。结论:血浆AGEs及LIS评分可用于预测ALI患者转归。Objective： To explore the role lung injury score （LIS） and advanced glycation end prod- ucts （AGEs） in the treatment outcome prediction of patients with acute lung injury （ALI）. Methods： Plas- ma AGEs concentration of 30 patients with ALI were evaluated by enzyme-linked immunosorbent assay （ELISA）, and lung injury score （LIS） were calculated. Based on the treatment outcome, these patients with ALI were divided into death group （n-=8） and survival group （n=22）, AGEs and LIS were compared between the two groups. Results： The AGEs and LIS of the death group were significantly different from that of the survival group （P〈0.05） a significant positive correlation was observed between AGEs andLIS （r=0. 926, P〈0.01）. Conclusion： Plasma levels of AGEs and LIS score can be used to predict the treatment outcome of patients with ALI.

关 键 词：急性肺损伤 晚期糖基化终末产物 肺损伤评分 

分 类 号：R56[医药卫生—呼吸系统]