半胱氨酸、高敏C反应蛋白在2型糖尿病合并视网膜病变中的变化分析  

Changes in cysteine,high sensitive C reactive protein in type 2 diabetic patients with retinopathy

作　　者：张丽敏[1] 叶苗苗[1] 吴慧芬[1] 胡鸿伟 陈芳[1] 陈少珍[1] 

机构地区：[1]海南省干部疗养院内二科,海南海口571100

出　　处：《海南医学院学报》2013年第2期194-196,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210516)~~

摘　　要：目的:根据2型糖尿病视网膜的病变特点,分析半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)的变化及其临床意义。方法:选取153例糖尿病患者为研究对象,根据视网膜病变情况分为糖尿病无视网膜病变组(105例),背景期DR组(27例),增殖期DR组(21例),并选取同期体检的正常人群为对照组(30例)。记录病程,比较各组人群血糖值、hs-CRP、Hcy,分析其临床意义。结果:随着眼底病变的进展,背景期DR组、增殖期DR组FPG、hs-CRP、Hcy均显著高于对照组或糖尿病无视网膜病变组(P<0.05),随着糖尿病的进展,背景期DR患者已经出现Hcy、hs-CRP水平的升高,显著高于正常人群;而在增殖期DR患者中上述指标升高更为明显,已明显高于无视网膜病变的糖尿病患者(P<0.05)。糖尿病视网膜病变患者Hcy与hs-CRP呈正相关(P<0.01)。结论:2型糖尿病视网膜病变患者Hcy、hs-CRP均显著高于正常人群,在增殖期DR患者中上述指标的异常更为明显,联合检测可更全面评估2型糖尿病视网膜病变的程度。Objective. To analyze changes in cysteine （Hcy）, high sensitivity C reactive protein （hs-CRP） in type 2 diabetic patients with retinopathy according to the pathological characteristics of the disease and their clinical significance. Methods.A total of 153 cases of patients with diabetes were enrolled and divided into no retinopathy group （n= 105 cases）, background DR group （n= 27 cases）, and prollfera-tion of DR group （n=21 cases）, 30 healthy volunteers were also enrolled as control group （n=30 cases）. Disease course, and glucose level, hs-CRP and Hcy level were recorded and compared among these groups. Results： FPG, hs-CRP and Hey levels in background DR group, proliferation of DR group （n=21 cases） were significant higher than that in control group or no retinopathy group （P〈0.05）. In patients with retinopathy, Hcy were positively correlated with hs-CRP （P〈0. 01）. Conclusion. In patients with type 2 diabetic retinopathy, Hcy, hs-CRP were significant higher than that of healthy people, especially for patients with proliferative phase of DR. Combined detection of Hcy and hs-CRP can evaluate the sever- ity of retinopathy in type 2 diabetes mellitus.

关 键 词：高敏C反应蛋白 同型半胱氨酸 糖尿病视网膜病变 

分 类 号：R587.1[医药卫生—内分泌]