冠状动脉介入治疗对冠心病患者血浆超敏C反应蛋白和白细胞介素6水平的影响  

Effects of percutaneous coronary interventional procedures on plasma levels of high sensitive C-reactiveprotein and interlekin-6 in patients with coronary artery disease

作　　者：刘丽军[1] 马燕霞[1] 冯慧旻[1] 邵丽莉[1] 裴利敏[1] 李琴[1] 孟利民[1] 李书香 

机构地区：[1]河北省邯郸市第一医院心内科,056002 [2]邯郸市峰峰矿区中医院外科

出　　处：《中国综合临床》2013年第3期275-277,共3页Clinical Medicine of China

基　　金：河北省医学科学研究重点课题计划项目（07150）

摘　　要：目的探讨冠状动脉介入治疗对冠心病患者炎症指标及术后再狭窄的影响。方法连续入选经冠状动脉介入治疗单支病变的冠心病患者90例（介入组），经冠状动脉造影证实冠状动脉正常的40例作为对照组。分别采用免疫浊度法和酶联免疫吸附法检测人选患者冠状动脉介入治疗前后超敏C反应蛋白（hs-caP）和白细胞介素6（IL-6）的浓度。结果（1）介入组患者术后血浆hs．CRP为（18．69±5．14）mg／L，显著高于术前的（14．45±4．32）mg／L，差异有统计学意义（t=1．42，P〈0．01）；而对照组冠状动脉造影术后hs-CRP为（13．59±5．99）mg／L，与术前的（12．46±5．35）mg／L相比，差异无统计学意义（t＝1．25，P〉0．05）。（2）介入组患者术后血浆IL-6为（1．87±0．45）pg／L，显著高于术前的（1．35±0．39）pg／L，差异有统计学意义（t=1．33，P〈0．01）；而对照组冠状动脉造影术后IL-6为（1．32±0．41）pg／L，与术前的（1．21±0．38）pg／L相比，差异无统计学意义（t=1．16，P〉0．05）。（3）介入组术后与对照组比较，血浆hs-CRP和IL-6差异有统计学意义（t=4．96、t=6．61，P均〈0．01）。结论冠状动脉介入治疗促进冠心病患者血浆hs-CRP及IL-6的升高，是否为冠状动脉介入治疗术后支架内再狭窄的重要机制之一尚待进一步考证。Objective To investigate the impact of percutaneous coronary interventional（PCI） on the inflammatory indices and postoperative vascular restenosis. Methods This study involved 90 patients undergoing PCI procedures for Coronary artery disease （CAD） compromising a single coronary artery. Fourty healthy individuals with normal findings by coronary angiography were selected as the control group. Before and after PCI or coronary angiography, plasma hs-CRP and IL-6 were measured in all the subjects by immunonephelometry and enzyme-linked immunosorbant assay （ ELISA）, respectively. Results （ 1 ） In the CAD patients,the plasma hs-CRP level was significantly elevated after PCI as compared with the preoperative level（ （ 18.69 ± 5. 14） mg/L vs （ 14.45 ± 4. 32 ） mg/L, t = 1.42, P 〈 0. 01 ）, whereas in the control group, the hs-CRP level underwent no significant changes after coronary angiography（ （ 13. 59 ± 5.99） mg/L vs（ 12.46 ± 5.35 ） rag/L, t = 1.25, P 〉 0.05 ）. （2） PCI procedures also resulted in significant elevation of plasma IL-6 level in the CAD patients（ （ 1.87 ± O. 45 ） pg/L vs （ 1.35 ± 0. 39） pg/L, t = 1.33, P 〈 O. 01 ）, but in the control group,IL-6 showed no significant variation after coronary angiography（ （ 1.32 ± 0.41 ） pg/L vs （ 1.21 ± 0. 38 ） pg/L,t = 1.16,P 〉0.05）. We observed significant difference of hs-CRP and IL-6 levels between the CAD patient group and the control group （ t = 4. 96,6. 61 respectively, P 〈 0. 01 ）. Conclusion Plasma hs-CRP and IL-6 are elevated in CAD patients following PCI procedures. But the roles of elevated hs-CRP and IL-6 in the vascular restenosis following the procedures need further investigation.

关 键 词：冠心病 C反应蛋白 白细胞介素6 

分 类 号：R541.4[医药卫生—心血管疾病]