血尿酸水平与帕金森病病情分级的相关性研究  

Correlation of serum uric acid levels with the progression of parkinson＇s disease

作　　者：李献军[1] 刘永[2] 孟丽[1] 张军[1] 王学明[1] 宋哲[1] 

机构地区：[1]河北省石家庄市第一医院神经内科,050011 [2]2石家庄市职业病防治院放射卫生防护所

出　　处：《中国综合临床》2013年第3期278-280,共3页Clinical Medicine of China

摘　　要：目的探讨血尿酸水平与帕金森病临床分期、认知功能损害的关系。方法对符合入选标准的帕金森病患者作为帕金森病组（60例），登记病史及进行详细查体，测定UPDRSnl量表，进行Hoehn-Yahr分期及简易智能状态评分（MMSE）量表测定；同时收集与帕金森病组年龄、性别、教育程度等相匹配的同期健康体检者作为对照组（52名）。两组均测定空腹血尿酸，对结果进行相应的统计学分析。结果帕金森病组血尿酸水平明显低于对照组[（262．4±85．2）μmol／L和（357．6±73．3）μmol／L]（t=1．013，P=0．005）；帕金森病患者Hoehn—Yahr分期各期之间的血尿酸水平相比较分析无等级相关性（r=0．143，P〉0．05）；各期帕金森病患者的血尿酸水平比较差异无统计学意义（F=1．014，P=0．064）；帕金森病组与对照组MMSE分值比较差别无统计学意义（26．12±2．87及28．32±2．17）（t=1．970，P=0．073）。结论帕金森病患者血尿酸水平降低很可能为帕金森病的危险因素之一。但不可以用来评定疾病严重程度。MMSE对于判定帕金森病认知功能损害不够敏感。Objective To discuss the relationships between serum uric acid levels and clinical stages, cognitive dysfunction in parkinson＇ s disease （ PD ）. Methods Sixty patients of PD were enrolled, and their history,detailed physical examination UPDRS m scale and mini-mental state score （MMSE） scale were performed to determine the Hoehn-Yahr stage of patients. At the same time 52 cases of healthy person were collected from the Health Examination Centers whose age, sex, and education matched with PD group as control group. The levels of serum uric acid in the two groups were examined and compared. Results The sel＇um uric acid levels in PD group were significantly lower than those in normal control group（ （262. 4 ± 85.2） μmol/L vs （357.6 ± 73.3 ） μmol/L） （ t = 1. 013, P = O. 005 ） ; There was no level correlation between different Hoehn- Yahr stage period of PD group （ r = 0. 143, P 〉 0. 05 ） ; There was no significant difference on serum uric acid levels between subgroup of PD patients（F = 1. 014,P = O. 06） ;The MMSE score between PD group and normal control group had no significant difference （26. 12 ± 2. 87 vs 28.32 ± 2. 17） （t = 1. 970, P = 0.073）. Conclusion Low level of the serum uric is likely to be a risk factor for PD, but cannot be used to assess the severity of disease and MMSE scale used to determine the cognitive impairment in PD is not sensitive enough.

关 键 词：帕金森病 血尿酸 认知功能损害 

分 类 号：R742.5[医药卫生—神经病学与精神病学]