冠心病合并糖代谢紊乱患者载脂蛋白变化及其临床意义  

Change of Apolipoproteins in Coronary Heart Disease Patients with Glucose Metabolism Disor- der and Their Clinical Significance

作　　者：阳毅临[1] 郑昭芬[1] 何晋[1] 

机构地区：[1]湖南师范大学第一附属医院心血管内科,湖南长沙410002

出　　处：《医学临床研究》2013年第1期142-144,共3页Journal of Clinical Research

摘　　要：【目的】观察载脂蛋白在冠心病和冠心病合并糖代谢紊乱患者中的变化及其，1盘床意义。【方法】采用全自动生化分析仪检测冠脉造影正常者48例（A组）、冠心病120例（B组）、冠心病合并糖代谢紊乱85例（C组）的空腹血糖、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（ApoAl）、栽脂蛋白B（ApoB）并计算ApoAl与ApoB的比值，并进行对比。【结果】B组及C组较A组HDL-C、ApoAl、ApoAl／ApoB明显下降（P〈0．05），LDL-C、ApoB明显增高（P〈0．05），C纽较B组，HDL-C、Ap0A1明显下降（P〈0．01）。【结论】冠心病合并糖代谢紊乱患者较冠心痛患者载脂蛋白紊乱更明显，主要表现为ApoAl下降，而ApoB无进一步变化。[Objective] To observe the change of apolipoproteins in patients with coronary heart disease and patients with coronary heart disease and glucose metabolism disorder, and to explore their clinical value. [Methods] A total of 48 subjects with normal coronary angiography（Group A）, 120 patients with coronary heart disease（Group B） and 85 patients with coronary heart disease and glucose metabolism disorder（Group C） were enrolled in this study. The fasting blood glucose, high-density lipoprotein cholesterol（HDL-C）, low den- sity lipoprotein cholesterol（LDL-C）, apolipoprotein A1 （ApoA1） and apolipoprotein B（ApoB） we＇re measure by using automatic biochemical analyzer. The ratio of ApoA1 to ApoB was calculated. These data were com- pared. [Results]Compared with group A, HDL-C, ApoA1 and ApoA1/ApoB of group B and group C de- creased significantly（ P d0.05）, while LDL-C and ApoB increased obviously（ P d0.05）. Compared with group B, HDL-C and ApoA1 of group C decreased evidently （ P d0.01）. [Conclusion] Compared with pa- tients with coronary heart disease, apolipoprotein disorder in patients with coronary heart disease and glucose metabolism disorder is more apparent. The main manifestation was the decreasing of ApoA1 and no further change of ApoB.

关 键 词：冠心痛 并发症 葡萄糖代谢障碍 载脂蛋白类 

分 类 号：R541.4[医药卫生—心血管疾病]