BIS监测下靶控输注丙泊酚在维、汉族中的临床观察  

Clinical Observation of BIS Monitored Propofol Target-controlled Infusion in Uygur and Han Patients

作　　者：张哲哲[1] 努尔波拉提·加列力汉[1] 蒋晖[1] 

机构地区：[1]新疆医科大学第三附属医院麻醉科,新疆乌鲁木齐830011

出　　处：《医学临床研究》2013年第1期145-147,共3页Journal of Clinical Research

摘　　要：[目的]4g讨脑电双频指数（BIS）监测下靶控输注丙泊酚在维、汉族中的差异。【方法】随机选择维吾尔族和汉族将择期行全麻的ASAI～Ⅱ级患者各60例，两组均根据设定的BIS值（BIS值为50）调整丙泊酚血浆靶浓度，比较两组静注丙泊酚达到设定的BIS值时（T1）、气管插管即刻（T2）、插管后5min（T3）时的丙泊酚血浆靶浓度及全麻诱导期间不良事件发生率。【结果】A组T1时的丙泊酚血浆靶浓度（5．27±1．02）μg／mL与B组（6．61±1．30）μg／mL比较差异有统计学意义（P〈0．05）；A组低血压和心动过缓不良事件发生率与B组比较有统计学意义（P〈O．05），而呛咳、呼吸肌强直、心动过速、高血压、低血压不良事件发生率与B组比较无统计学意义（P〉0．05）。【结论】维、汉族全麻诱导时达到设定的BIS时丙泊酚的血浆靶浓度和诱导期间发生的不良事件有差异，为指导临床工作中雏、汉两族患者全麻诱导时丙泊酚的用量及预防全麻诱导时不良事件的发生提供理论基础。[Obiective] To explore the difference of bispectral index（BIS） monitored propotol target-con- trolled infusion between Uygur and Han patients. [Methods] Sixty ASAI ~ I1 Uygur patients and 60 Han patients scheduled for general anesthesia were randomly selected. According to the setting BIS value（BIS value was 50）, the plasma target concentration of propofol in two groups was adjusted. Plasma target concentration of propofol and the incidence of adverse events during general anesthesia induction at the time of intravenous propofol reaching the setting BIS valus（T1）, at tracheal intubation immediately（Tz） and 5min after intubtion （T~） were compared between two groups. [Results] There was significant difference in plasma target concen- tration of propofol at Ta between group A and group B[-（5.27：t：1.02）tag/mL vs （6.61~1.30）tag/mL, P ＂~ 0. 051. There was significant difference in the incidence of adverse events such as hypotension and bradycardia between group A and group B（ P d0.05）. But there was no significant difference in the incidence of adverse events such as bucking, respiratory muscle rigidity, tachycardia, hypertension and hypotension between group A and group B（ P ~0.05）. [Conclusion] There is the difference in plasma target concentration of propofol when reaching the setting BIS under general anesthesia induction and the incidence of adverse events during the induction between Uygur and Han patients. It can provide the theoretical basis for guiding the dosage of propofol at general anesthesia induction and preventing the incidence of adverse events at general anesthesia in- duction in Uygur and Han patients in clinical practice.

关 键 词：二异丙酚 投药和剂量 少数民族 

分 类 号：R971.2[医药卫生—药品]