超声促进对甲苯磺酸催化的三组分Mannich反应  

Ultrasound Promoted Three-component Mannich Reaction Catalyzed by p-toluenesulfonic Acid Irradiation

作　　者：张玉全[1] 

机构地区：[1]陇东学院化学化工学院,甘肃庆阳745000

出　　处：《陇东学院学报》2013年第1期30-32,共3页Journal of Longdong University

摘　　要：超声辐射条件下对甲基苯磺酸催化酮与芳香醛、芳香胺的三组分Mannich反应生成合成β-胺基酮衍生物,该方法产率高、反应条件温和、操作简单,更重要的是,超声波条件下首次合成具有脂肪环基β-胺基酮衍生物.p-toluenesulfonic acid （p-TsOH）-catalyzed three-component Mannich reaction of ketones, aro- matic aldehydes and aromatic amines promoted by ultrasound gave the corresponding β-amino ketones This ultrasound protocol has advantages of high yield, mild condition, simple work-up procedures. Most importantly, cyclicaliph- atic β-aminocarbonyl compounds are obtained by this methodology for the first time.

关 键 词：MANNICH反应 超声波 β-胺基酮衍生物 对甲基苯磺酸 

分 类 号：O621.125[理学—有机化学]