胱抑素C、C反应蛋白及尿微量白蛋白联合检测在糖尿病肾损伤诊断中的意义  

The clinical value of determination of CysC,CRP and UMA in patients with DN

作　　者：王金华[1] 马丽媛[1] 蒋为[1] 

机构地区：[1]大连市第二人民医院检验科,辽宁大连116012

出　　处：《中国冶金工业医学杂志》2013年第1期3-4,共2页Chinese Medical Journal of Metallurgical industry

摘　　要：目的探讨胱抑素C(CysC)、C反应蛋白(CRP)及尿微量白蛋白(UMA)联合检测在糖尿病肾损伤诊断中的意义。方法选取96例2型糖尿病(T2DM)患者分为两组,其中糖尿病未发生肾脏病变即单纯糖尿病(SDM)组54例,糖尿病肾病(DN)组42例,另设对照组为48例健康体检者。利用全自动生化分析仪检测其静脉血中CysC、CRP及尿中UMA含量,并常规检测肌酐(CRE)的含量做为对照分析。结果 SDM组CysC、CRP、UMA与正常对照组比较差异有统计学意义(P<0.05),而CRE与正常对照组比较差异无统计学意义(P>0.05);DN组CysC、CRP、UMA与正常对照组及SDM组比较差异有统计学意义(P<0.05)。SDM组CysC、CRP、UMA三者联合检测阳性率为91%,显著高于单项检测(P<0.05)。结论 CysC、CRP、UMA是糖尿病早期肾损伤的敏感指标,监测患者三项指标的动态变化,可以早期发现糖尿病肾损伤,为临床诊治提供依据。Objective To investigate the clinical value of determination of serum Cystatin C and high-Sensitivity C reactive protein and Urinary albumin in patients with diabetic nephropathy diagnosis. Methods Ninety-six patients with type 2 diabetes mellitus（T2DM）were divided into SDM group（54 cases）without diabetic nephropathy and DN group（42 cases）with diabetic nephropathy and other healthy physical subjects（48 cases）were as control group. CysC, CRP, UMA and CRE were examined by automatic biochemical analyzer. Results In SDM and DN group,CysC,CRP, UMA were significantly higher than those in the normal control group directly（P〈0. 05）. But CRE was higher only in DN group. The positive rate of combined detection for CysC,CRP, UMA was 91%,obviously higher than that of single test. Conclusion CysC, CRP, UMA were the sensitive indicators of early kidney damage,and their joint detection would discover kidney damage early which provide evidence for clinical diagnosis.

关 键 词：胱抑素C C反应蛋白 尿微量白蛋白 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]