儿童分次注射IPV、Hib和DTaP疫苗与注射联合疫苗的对比分析  

Comparative analysis of the side effects of DTaP-IPV/Hib combined vaccine with injection of DTaP, IPV and Hib separately in healthy Chinese infants

作　　者：陈杰[1] 刘芳[1] 石劢[1] 张勇[1] 范钦颖[1] 王琳[1] 

机构地区：[1]中日友好医院预防保健科,北京100029

出　　处：《中日友好医院学报》2013年第1期16-17,29,共3页Journal of China-Japan Friendship Hospital

摘　　要：目的:比较注射单剂吸附无细胞百白破联合疫苗(DTaP)、脊髓灰质炎灭活疫苗(IPV)及B型流感嗜血杆菌疫苗(Hib)与DTaP-IPV/Hib五联疫苗(简称五联疫苗)接种后的副反应,探求合理有效的疫苗接种方式。方法:在我院免疫接种的600例健康婴幼儿,按照监护人自愿原则分为2组,第1组分次注射DTaP、IPV和Hib,第2组注射五联疫苗,接种48h后随访2组婴幼儿副反应情况,并对2组副反应临床表现、强弱、接种针次与副反应的关系进行比较。结果:不同方式预防接种2组婴幼儿副反应临床表现强弱、接种针次与副反应之间均无显著性差异(均P>0.05)。结论:五联疫苗的副反应与常规单剂免疫接种相似,它简化了免疫程序,应推荐接种。Objective：To compare the side effect of separately injection of inactivated polio vaccine（IPV）, Haemophilus influenzae type B vaccine（Hib）and adsorption of acellular DTP vaccine（DTaP）with DTaP-IPV/Hib combined vaccine and explore the more reasonable and effective inoculation approach.Methods：A total of 600 healthy infants in the hospital were randomly divided into two groups according to the principle of voluntary participation.The Group 1 was immunized with IPV,Hib and DTaP seperately,while the Group 2 was injected DTaP-IPV/Hib combined vaccine.Adverse reactions within 48 hours after injection were followed-up of the two groups.Comparative analysis was carried out on the side effects of manifestation,degree and doses of the two groups.Results：There were no significant differences in side effects of manifestation,degree and doses of the two groups（all P〉0.05）.Conclusion：The combined vaccine DTaP-IPV/Hib is safe and effective.It simplifies the inoculation procedure and is recommended in vaccination.

关 键 词：疫苗 预防接种 副反应 

分 类 号：R186[医药卫生—流行病学]