8-氟-5-甲氧基-1,2,4-三唑并[4,3-c]嘧啶-3(2H)-硫酮的合成  

Pratical Preparation of 8-fluoro-5-methoxy-2H-[1,2,4]triazolo[4,3-c] pyrimidine-3-thione

作　　者：刘敬[1] 沈小娟[1] 吴晓伟[1] 马鸿飞[1] 左杭冬[1] 卜洪忠[1] 李玉峰[1] 

机构地区：[1]南京工业大学理学院,江苏南京211816

出　　处：《广东化工》2013年第4期7-8,共2页Guangdong Chemical Industry

摘　　要：以5-氟尿嘧啶为起始原料,经氯代反应、醇解反应、肼解反应和环合反应合成了高效除草剂双氟磺草胺的关键中间体—8-氟-5-甲氧基-1,2,4-三唑并[4,3-c]嘧啶-3(2H)-硫酮。以5-氟尿嘧啶计,产品总收率达70.1%,产品结构经核磁共振分析验证。探讨了原料配比、反应温度、时间等因素对反应收率的影响。Using 5-fluorouracil as starting material, 8-fluoro-5-melhoxy-2H-[l,2,4]triazolo[4,3-c]pyrimidine-3-thione was synthesized by chlorination, alcoholysis, hydrazinolysis, cyclization, in a total yield of 70.1%, which is a key intermediate of florasulam. The structure of 5-fluorouracil was confirmed by NMR analysis. The influence of the ratio of reactants, temperature and time factor on the yield was investigated.

关 键 词：8-氟-5-甲氧基-1 2 4-三唑并[4 3-c]嘧啶-3(2H)-硫酮 5-氟尿嘧啶 双氟磺草胺 合成 

分 类 号：TQ[化学工程]