急性心肌梗死患者血脂水平的增龄变化特点  

Variation of lipid profile in patients with acute myocardial infarction of different age groups

作　　者：魏勇[1] 刘少稳[2] 周根青 欧阳平[1] 费民忠[1] 

机构地区：[1]上海交通大学附属第一人民医院松江分院心内科,201600 [2]上海交通大学附属第一人民医院心内科

出　　处：《中华全科医师杂志》2013年第2期104-107,共4页Chinese Journal of General Practitioners

基　　金：上海交通大学附属第一人民医院松江分院院级课题（项目编号：BY09A08）

摘　　要：目的探讨急性心肌梗死（AMI）患者血脂水平的增龄变化特点。方法收集本院2007年5月至2011年7月符合入选标准的AMI患者1214例。依据年龄40—89岁间每10岁分为一组，比较各年龄组及不同性别间患者的血脂水平差异。结果在7个年龄组中进行两两间TC或LDL—C水平比较，40～69岁各年龄组的TC水平[分别为（4．71±1．08）、（4．80±1．30）、（4．69±1．03）mmol／L]均高于70～89岁各年龄组[分别为（4．41±0．96）、（4．38±1．03）mmol／L]，均P〈0．05（t值分别为2．381、2．323、4．382、3．965、3．317、3．096）。59岁以下的3个年龄组间的TG水平差异无统计学意义，该3组的TG水平均高于60岁以上各年龄组；在50—89岁患者TG水平随年龄组的增加而逐渐降低。7个年龄组间的HDL—C水平两两比较，40—59岁各年龄组的HDL—C水平[分别为（1．03-4-0．23）、（1．05±0．26）mmol／L]均低于60～89岁各年龄组[分别为（1．11±0．28）、（1．11±0．28）、（1．16±0．34）mmol／L]，均P〈0．05（t值分别为-2．777、-2．789、-3．731、-2．543、-2．566、-3．644）。AMI患者TC（r=-0．123，P〈0．01）、LDL—C（r=-0．139，P〈0．01）和TG（r=-0．287，P〈0．01）与年龄呈负相关，HDL—C与年龄呈正相关（r=0．125，P〈0．01）。1214例AMI患者中，50～89岁各年龄组的女性TC水平高于同年龄组男性，50～69岁各年龄组的女性LDL—C水平高于同年龄组男性，40～79岁各年龄组的女性HDL—C水平高于同年龄组男性，均P〈0．05（t值分别为-2．878、-3．007、-3．352、-3．333）。结论总体上看，〈60岁的AMI患者的TC、LDL和TG高于≥60岁老年AMI患者，而HDL偏低。同年龄组女性TC、LDL、HDL水平有高于男性的趋势。Objective To investigate the variation of lipid profile in patients with acute myocardial infarction （AMI） of different age groups. Methods Total 1214 patients of AMI were admitted to our hospital from May 2007 to July 2011. The age of patients ranged 40 -89 years, and patients were divided into 5 age groups with 10-years step. Differences in lipid levels were observed by using pair-wise comparison among different age groups. Results Pair-wise comparisons among different age groups indicated that TC levels were higher in 40 -69 years age groups [ （4. 71 ± 1.08）, （4. 80± 1.30）, （4. 69 ±1.03） mmol/L, respectively] than those in the 70 -89 age groups （4.41 ±0. 96）, （4. 38 ± 1.03） mmol/L], all P 〈0. 05 （t values were 2. 381,2. 323,4. 382,3.965,3. 317,3. 096）. TG levels among three age groups 〈 59 years had no significant difference, which were higher than those in groups over 60 years. Among 50 - 89 years age groups, TG gradually reduced with increase of age. HDL levels were lower in 40 -59 years age groups （ 1.03 ±0. 23）, （ 1.05 ±0. 26） retool/L, respectively] than those in 60 -89 years age groups [ （ 1.11± 0.28）, （1.11±0.28）, （1.16 ±0.34） mmol/L, respectively], allP〈0.05 （t values were -2.777, -2. 789, -3. 731, -2. 543, -2. 566, -3. 644）. Total cholesterol （TC） （r = -0. 123, P 〈0.01 ）, low- density lipoprotein cholesterol （LDL） （r = - 0. 139, P 〈 0. 01 ） and triglyceride （TG） （r = - 0. 287, P 〈 0. 01 ） were negatively but high-density lipoprotein cholesterol （HDL） （ r = 0. 125, P 〈 0. 01 ） was positively correlated with age of patients. TC levels in female patients were higher than those in male patients in 50 -89 years age groups; LDL levels in female patients were higher than those in male patients in 50 -69 years age groups and HDL levels in female patients were higher than those in male patients in 40 -79 years age groups （all P 〈 0. 05, t values were - 2. 878, - 3. 007, - 3. 352, - 3. 333）. Conc

关 键 词：血脂异常 心肌梗死 年龄分布 

分 类 号：R542.22[医药卫生—心血管疾病]