中药地榆槐花汤联合甲氨蝶呤治疗银屑病关节炎临床观察  

Clinical Observation on treatment of Diyu Huaihua Decoction combined with Methotrexate Combination for Psoriatic Arthritis

作　　者：白云静[1] 申洪波[2] 姜德训[1] 安娜 

机构地区：[1]北京军区总医院,北京100700 [2]北京大学第三医院

出　　处：《世界中医药》2013年第1期40-42,共3页World Chinese Medicine

摘　　要：目的:观察中药地榆槐花汤联合甲氨蝶呤治疗银屑病关节炎(PsA)的临床疗效和安全性。方法:采用随机对照研究方法,将51例PSA患者随机分为2组,即对照组(25例)和治疗组(26例),对照组给予甲氨蝶呤治疗,治疗组在此基础上给予自拟地榆槐花汤加减治疗,疗程12周,观察2组患者治疗前后相关临床及实验室指标的变化。结果:治疗12周后,2组患者在VAS评分、晨僵时间、关节肿胀数、关节压痛数、血沉、C反应蛋白和皮损PASI评分等方面较治疗前均有明显改善(P均<0.05),且2组差值比较治疗组在上述方面改善均较对照组有统计学意义(P均<0.05);对照组不良反应发生率明显高于治疗组(P<0.05)。结论:中药自拟地榆槐花汤加减联合甲氨蝶呤治疗PsA能明显改善关节症状,减轻皮损,具有良好的临床疗效,且不良反应较小,值得临床推广应用。Objective：To observe the clinical efficacy and safety of Diyu Huaihua decoction combinde with methotrexate in treating pso-riatic arthritis, nethods：A randomized controlled study was conducted. 51 cases of PSA were randomly divided into two groups, the control group （25 cases） was given methotrexate therapy while the treatment group （26 cases） was given Diyu Huaihua decoction and methotrexate combination treatment for 12 weeks, observed the changes of clinical and laboratory parameters in the two groups of patients before and after treatment. Results：After 12 weeks of treatment, compared with pre-treatment, the VAS score, duration of morning stiff- ness, swollen joint count, tender joint count, ESR, C-RP and skin lesions PASI score of the two groups showed significant improvement （P 〈 0. 05 ）, and compared with the control group, the differences of these index in treatment group before and after treatment were sig- nificant（P 〈 0.05 ） ; the incidence of adverse reactions was significantly higher in control group when compared with treatment group （P 〈 0. 05）. Conclusion：Diyu Huaihua decoction combined with methotrexate combination can significantly improve joint symptoms, relieve skin lesions and has smaller adverse reactions.

关 键 词：银屑病关节炎 中医药疗法 @地榆槐花汤 甲氨蝶呤 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]