骆驼蓬碱和去氢骆驼蓬碱的质谱裂解途径研究  

The ESI /MS Study on the Fragmentation Pathways of the Harmaline and Harmine

作　　者：张洪亮[1,2] 谭鹏[1] 邬瑞光[1] 罗玲娟[2] 韩静[1] 王春国[1] 邓昕祺[1] 刘永刚[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]新疆医科大学中医院,乌鲁木齐830028

出　　处：《世界中医药》2013年第1期85-86,共2页World Chinese Medicine

基　　金：国家自然科学基金(编号:30901959)

摘　　要：目的:研究去氢骆驼蓬碱和骆驼蓬碱的质谱裂解机制。方法:两者用HPLC进行分离后,在正离子模式下,得到去氢骆驼蓬碱和骆驼蓬碱的质谱图。结果:解析了去氢骆驼蓬碱和骆驼蓬碱多级质谱碎片,主要发生RDA裂解、-CH3和-OH等自由基丢失,吲哚环稳定。结论:本研究丰富了去氢骆驼蓬碱和骆驼蓬碱的质谱裂解机制,为β-咔啉类生物碱的成分研究提供依据。Objective ：To study the fragmentation pathways of harmaline and harmine by etectrospray ionization mass spectrometry （ ESI- MSn）. Methods：Harmaline and harmine were analyzed by ESI-MSn in positive ion mode. The first and multi-stage mass spectrum dia- grams were obtained. Results： To analyze mass spectrometry fragments of the harmaline and harmine, under the positive mode, RDA decomposition occurred mainly, and - CH3, -OH were lost. Conclusion： The results enriched the mass spectrum decomposition, and provided the basis for the chemical constituents research of B-carboline alkaloid.

关 键 词：骆驼蓬碱 ESI—MS MS 裂解途径 去氢骆驼蓬碱 

分 类 号：R979.1[医药卫生—药品]