HIV-1感染者血清IL-18及IL-18BP水平的变化及临床意义  

Clinical Significance of Changes of Interleuking-18 and Interleuking-18 Binding Protein Levels in Serum of HIV-infected Patients

作　　者：黄甲清[1] 张英[1] 蒋就喜[1] 胡婷婷[1] 李赫伟[1] 曾思恩[1] 徐茹 沈建峰[3] 谢付静[4] 

机构地区：[1]桂林医学院附属医院,广西桂林541001 [2]桂林市第三人民医院,广西桂林541001 [3]淮南市东方医院集团总院,安徽淮南232007 [4]聊城市人民医院,山东聊城252000

出　　处：《广西师范大学学报（自然科学版）》2012年第4期110-114,共5页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金资助项目(30460141);广西本级技术研究与开发项目(桂财教[2010]124号;桂财教[2012]98号);广西教育厅科研项目(桂教科研[2007]34号);广西医疗卫生重点科研课题基金资助项目(重2010055);桂林市科学研究与技术开发项目(市科[2010]37号)

摘　　要：为了观察HIV-1阳性病人血清IL-18和IL-18BP水平与疾病的关系,用ELISA法检测67例经HAART治疗的HIV-1阳性病人及18例正常对照者血清的IL-18和IL-18BP水平。结果显示,HIV-1感染组血清IL-18水平明显高于正常对照组(P<0.01),其中A类HIV-1感染组IL-18水平高于正常对照组(P<0.05),B类、C类HIV-1感染组IL-18水平明显高于正常对照组(P<0.01);HIV-1感染组血清IL-18BP的水平明显高于正常人(P<0.01),其中各类HIV-1感染组IL-18BP水平均高于正常对照组(P<0.05);正常对照组IL-18和IL-18BP水平呈正相关(r=0.705,P<0.01),HIV-1感染组的IL-18和IL-18BP水平无相关性。可见,IL-18和IL-18BP水平的变化及失衡与艾滋病的发生、发展相关,动态监测外周血IL-18及IL-18BP水平可作为反映HIV-1感染者的免疫功能状态变化指标,调节体内IL-18、IL-18BP水平的平衡可能为艾滋病治疗提供新途径。To investigate the clinical significance and changes of IL-18and IL-18BP in serum in HIV-infected patients,the levels of IL-18 and IL-18BP in serum were detected by ELISA in 67 cases of HIV-1 infestors with HAART and 18 cases of healthy persons. The levels of IL-18 in serum of HIV-1 group were significantly higher than those of control group （P〈0. 01）,the levels of IL-18 in serum of HIV-1group A were higher than those of control group （P〈0. 05）;The levels of IL-18 in serum of HIV-1 group B and HIV-1 group C were significantly higher than those of control group （P〈0.01） ;The levels of IL-18BP in serum of HIV-1 group were significantly higher than those of control group （P〈O. 01）, the levels of IL-18 in serum of three HIV-1 groups were higher than those of control group （P〈0.05） ; A significant positive correlation was found between the levels of IL-18 and IL-18BP in healthy persons （r=0. 705,P〈0.01）. The levels of IL-18 had no correlation with the levels of IL-18BP in serum of three HIV-1 groups. Increased levels of IL-18 and IL-18BP may play important roles in the occurrence and progression of AIDS,and the imbalance between IL-18 and IL-18BP may participate in it too. Dynamic monitoring of IL-18 and IL-18 BP in peripheral blood can be used as a reflection of the immune function of state changes index in HIV-1 infected patients. Regulating the balance between IL-18 and IL-18 BP may provide a new approach for the treatment of AIDS.

关 键 词：HIV-1 白细胞介素-18 白细胞介素-18结合蛋白 

分 类 号：R512.91[医药卫生—内科学]