36例药物致急性肾损伤（AKIN诊断标准）的临床治疗研究  

Clinical Study of 36 Patients with Drug-induced Acute Kidney Injury （AKIN diagnostic criteria）

作　　者：陶怡婷[1] 白云凯[1] 谭向来[1] 周竹[1] 

机构地区：[1]昆明医学院第一附属医院肾内科,云南昆明650032

出　　处：《医学信息》2013年第4期93-94,共2页Journal of Medical Information

基　　金：云南省科技厅与昆明医科大学联合基金项目（2011FB180）

摘　　要：目的观察药物致急性肾损伤中应用还原型谷胱甘肽的临床疗效。方法选取我科收住的36名药物致AKI第3期（AKIN标准诊断标准）患者，治疗组（20例）采用传统AKI治疗方法加用还原型谷胱甘肽，对照组（16例）采用传统方法，比较两组患者肾功能恢复情况。结果治疗组少尿期持续时间、血肌酐恢复时间较对照组明显缩短，差异具有统计学意义，t值分别为2．33和2．29（P〈005）。结论在药物致AKI的治疗中，以传统治疗方法加用还原型谷胱甘肽可以促进肾功能的恢复。Objectlve To observe the clinical efficacy of reduced glutathione in the drug induced acute kidney injury .Methods Our department admitted 36 Drug induced AKI （The AKIN Diagnostic criteria,the 3 stage） patients, the treatment group （20 cases） uses traditional AKI treatment and reduced glutathione , the control group （16 cases） uses the traditional method ,the two groups were compared with renal functional recovery. Results The oliguria duration of the treatment group, serum ereatinine recovery time compared with the control group was significantly shorter, a statistically significant difference, t values were 2.33 and 2.29 （P 〈0.05）.Conclusion In the treatment of drug induced AKI, using traditional treatment with reduced glutathione can promote the recovery of renal function.

关 键 词：还原型谷胱甘肽 药物致急性肾损伤 临床治疗效果 

分 类 号：R692[医药卫生—泌尿科学]