核苷(酸)类似物抗病毒治疗对慢性乙型肝炎患者细胞免疫功能的影响  

Effect of antiviral treatment with nucleoside and nucleotide analogues on cellular immune function in patients with chronic hepatitis B

作　　者：陈宇[1] 邱隆敏[1] 姚新生[2] 庄勤建[1] 吕红[1] 

机构地区：[1]遵义医学院附属医院感染科,贵州省遵义市563003 [2]遵义医学院免疫学教研室,贵州省遵义市563003

出　　处：《世界华人消化杂志》2012年第35期3521-3528,共8页World Chinese Journal of Digestology

摘　　要：我国是乙型肝炎病毒(hepatitis B virus,HBV)感染的高流行区,大样本的调查显示我国慢性HBV感染者高达1.2亿人之多.由于持续HBV感染及复制激发的免疫应答失调是慢性乙型肝炎(chronic hepatitis B,CHB)患者病情进展的根本原因,要阻止疾病进展,应进行有效的抗病毒治疗.核苷(酸)类似物是目前公认有效的抗HBV的药物之一,被广泛应用于临床,主要通过抑制DNA聚合酶的复制从而发挥抗HBV作用.其在有效抗病毒治疗的同时对机体细胞免疫功能有何影响.本文就近年来此方面的研究进展进行综述.China is a country where hepatitis B virus （HBV） infection is highly endemic, and a large sample survey shows that chronic HBV infection affects as many as 120 million people in China. Since immune response dysregulation caused by persistent HBV infection and replication is the underlying cause of disease progression in patients with chronic hepatitis B （CHB）, effective antiviral therapy should be given to halt the progression of the disease. Nucleoside and nucleotide analogues have been generally accepted as effective anti-HBV drugs and widely used in the clinical setting. They exert antiviral effects against HBV mainly by inhibition of DNA polymerase-mediated DNA replication. In addition, nucleoside and nucleotide analogues also have an impact on the body＇s immune function. In this article we review recent progress in understanding the effect of antiviral treatment with nucleoside and nucleotide analogues on cellular immune function in CHB patients.

关 键 词：核苷(酸)类似物 慢性乙型肝炎 细胞免疫 

分 类 号：R512.62[医药卫生—内科学]