间充质干细胞来源微泡的研究进展  

Research Progress of Mesenchymal Stem Cell-derived Microvesicle

作　　者：王晓庆[1] 朱晓健[1] 邹萍[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院血液病学研究所,湖北武汉430022

出　　处：《中国实验血液学杂志》2013年第1期227-230,共4页Journal of Experimental Hematology

基　　金：国家自然科学基金项目(编号81170525);中国医师协会临床医学科研专项资金-血液肿瘤临床研究基金(编号20100137)

摘　　要：间充质干细胞来源的微泡(MSC-MV)是MSC在静息或活化状态下释放到胞外的膜分泌体系,包括直径在100-1 000 nm的微粒(microparticle)和40-100 nm的外来体(exosome)。MSC-MV由脂质双分子层膜包被,其内选择性包裹脂质、蛋白质、mRNA及miRNA等多种生物活性物质。MSC-MV膜表面携带MSC的某些表面标记,可以通过配受体结合等方式被靶细胞摄取,并具有明确的减轻组织损伤程度、促进损伤组织形态学及功能学修复的作用,且该作用可能由其内含的miRNA外源传递所介导;MSC-MV可能还具有潜在的调节机体免疫、调控细胞生长分化等生物学功能。本文就MSC-MV的产生机制、组分及生物学功能作一综述。Mesenchymal stem cell-derived microvesicle （MSC-MV） is a membrane secretory system which includs microparticle and exosome, and MSC-MV is released by MSC in resting or activated state. MSC-MV selectively package the biological active substances such as lipids, proteins, mRNA and miRNA but not loads them randomly. It has definitive effect of reducing tissue injury, promoting morphological and functional recovery of the injured tissue, and this effect is probablely mediated by miRNA. What is more, the MSC-MV may also possess the biological function of immunological regulation, modulation of cell growth and differentiation. The generation, constitution, and function of MSC-MV are reviewed in this article.

关 键 词：间充质干细胞 微泡 组织修复 MIRNA 

分 类 号：R329.28[医药卫生—人体解剖和组织胚胎学]