生殖激素避孕疫苗现状及应用前景  

Development and application prospects of contraceptive vaccine targeting reproductive hormones

作　　者：杨利华[1] 梁志清[2] 商艳朝[3] 杨雅静[4] 李颖杰[5] 

机构地区：[1]河北医科大学附属唐山工人医院,唐山063020 [2]第三军医大学西南医院妇产科,重庆400038 [3]唐山市妇幼保健院,063020 [4]唐山市第二医院检验科,063020 [5]唐山市人民医院普外科,063020

出　　处：《免疫学杂志》2013年第3期264-266,共3页Immunological Journal

摘　　要：作为避孕疫苗的生殖激素抗原主要有:GnRH、FSH、LH及hCG。这些抗原显示了不同程度的避孕效应,其中,hCG疫苗是唯一进入Ⅱ期临床试验的避孕疫苗;而且,GnRH及hCG疫苗在非避孕方面具有广阔的应用前景。The molecules that being explored for contraceptive vaccine （CV） development mainly include reproductive hormones GnRH, FSH, LH and hCG. CV targeting the above-mentioned antigens has shown varieddegrees of contraceptive efficiency. The hCG vaccine is the first vaccine to undergo Phase I and Phase II clinical trials in humans. Moreover, both GnRH and hCG vaccines have an exciting application prospects in non-contraceptive fields.

关 键 词：避孕疫苗 生殖激素 避孕 

分 类 号：R392.7[医药卫生—免疫学]