血清总胆汁酸对早产儿胃肠外营养相关性胆汁淤积的诊断评价  

作　　者：李彤[1] 黄善周[1] 

机构地区：[1]广东省信宜市人民医院儿科,525300

出　　处：《当代医学》2013年第7期95-96,共2页Contemporary Medicine

摘　　要：目的探讨血清总胆汁酸对早产儿胃肠外营养相关性胆汁淤积的诊断意义。方法选取2010年1月～2012年3月广东省信宜市人民医院收治的早产儿118例,分为实验组(有胃肠外营养相关性胆汁淤积)和对照组(无胃肠外营养相关性胆汁淤积),记录全部早产儿的血清总胆汁酸(TBA)、谷氨酰转肽酶(GGT)及碱性磷酸酶(ALP)。结果 TBA的灵敏度和特异度均高于GGT、ALP指标,当血清TBA≥25.8μmol/L时,其灵敏度、特异度分别为88.3%和88.1%。结论血清TBA检测更利于胃肠外营养相关性胆汁淤积的早期诊断,具有重要的临床意义。Objective To investigate the diagnosis of Serum total bile acid on parenteral nutrition associated cholestasis for premature. Methods There were 118 premature in our hospital from Jan 2010 to Mar 2012 divided into the experiment group,which with parenteral nutrition associated cholestasis, and the control group, which without parenteral nutrition associated cholestasis. The experiment group used EMIC while the control group used three-hole method. Results The sensitivity and specificity of TBA were higher than GGT and ALP. The sensitivity and specificity of TBA were 88.3% and 88.1% when Serum total bile acid more than 25.8 μmol/L. Conclusion The serum total bile acid has an important clinic meaning, for whose detection is beneficial to early diagnosis for parenteral nutrition associated cholestasis.

关 键 词：血清总胆汁酸 早产儿 胃肠外营养相关性胆汁淤积 诊断 

分 类 号：R446.1[医药卫生—诊断学]