臭氧联合玻璃酸钠治疗膝关节骨性关节炎的临床疗效  

Efficacy of treating knee osteoarthritis with combined articular cavity injection of ozone and sodium hyaluronate

作　　者：叶雷[1] 陆丽娟[2] 张中军[1] 邹军[1] 

机构地区：[1]无锡市第三人民医院麻醉科,江苏省214041 [2]南京大学医学院附属鼓楼医院镇痛科

出　　处：《江苏医药》2013年第3期293-295,共3页Jiangsu Medical Journal

摘　　要：目的探讨臭氧联合玻璃酸钠治疗膝关节骨性关节炎的临床疗效。方法 90例膝关节骨性关节炎患者随机均分为三组:B组用35μg/ml臭氧10ml关节腔内注射;C组用玻璃酸钠2ml;A组应用臭氧联合玻璃酸钠。记录治疗前及治疗后第7天、1、3、6、12个月时患者的VAS疼痛评分、Lysholm膝关节功能评分及不良反应。结果治疗后,A组VAS评分降低和Lysholm评分增加程度均明显大于B、C组,持续时间最长。A组治疗优良率为93.33%,明显高于B组的80.00%(P<0.01)和C组的83.33%(P<0.05)。三组均未观察到明显的不良反应。结论臭氧联合玻璃酸钠膝关节腔内注射,疗效优于单用臭氧或玻璃酸钠。Objective To investigate the clinical efficacy of treating knee osteoarthritis（KOA） with combined articular cavity injection of ozone and sodium hyaluronate.Methods Ninety patients with KOA were treated with 35 μg/ml ozone 10 ml（group B,30 cases）,sodium hyaluronate 2 ml（group C,30 cases） and combined use of ozone and sodium hyaluronate（group A,30 cases）.Clinical efficacy was evaluated by VAS of pain and Lysholm scores of knee joint function before treatment and at the 7th day,1st,3rd,6th and 12th month after treatment.Results Compared to groups of B and C,the scores of VAS and Lysholm were improved more and clinical efficacy lasted longer in group A.The total effectiveness rate of group A was 93.33%,which was significantly higher than 80.00% of group B（P0.01） and 83.33% of group C（P0.05）.There were no obvious side effects in three groups.Conclusion Combined articular cavity injection of ozone and sodium hyaluronate has better efficacy than that of ozone or sodium hyaluronate alone.

关 键 词：臭氧 玻璃酸钠 膝关节骨性关节炎 

分 类 号：R684[医药卫生—骨科学]