HBsAg多肽刺激树突状细胞联合大黄蛰虫丸治疗肝纤维化的疗效  

Efficacy of HBsAg peptide-induced stimulated dendritic cells combined with Dahuangzhechongwan in treating hepatofibriosis

作　　者：白浩[1] 陆原[1] 郭海燕[1] 臧志栋[2] 时宏珍 邵铭[1] 

机构地区：[1]江苏省中医院感染病科,210029 [2]南京市第二医院肝病科 [3]南京得康生物技术有限公司

出　　处：《江苏医药》2013年第3期298-300,共3页Jiangsu Medical Journal

基　　金：江苏省中医药局资助项目(LZ09031)

摘　　要：目的探讨HBsAg多肽刺激树突状细胞(DCs)联合大黄蛰虫丸治疗肝纤维化的临床疗效。方法慢性乙型肝炎(CHB)或肝炎代偿期肝硬化患者45例,随机分为两组:治疗组25例,用DCs细胞联合大黄蛰虫丸治疗;对照组20例,仅用大黄蛰虫丸治疗。疗程均为3个月。检测并比较治疗前、治疗3个月和两组患者的肝功能(AST、ALT和谷氨酰转肽酶、肝纤维化指标(透明质酸和Ⅳ型胶原)及治疗有效率的B超评估。结果治疗组的中医症状、证候和肝功能、肝纤维化指标的改善均明显优于对照组(P<0.05或P<0.01);治疗组B超诊断的有效率也明显优于对照组(P<0.05)。结论 HBsAg多肽刺激的DCs联合大黄蛰虫丸治疗肝纤维化具有一定疗效。Objective To investigate the efficacy of HBsAg peptide-induced dendritic cells（DCs） combined with Dahuangzhechongwan（DZW） in the treatment of hepatofibriosis.MethodsFourty-five patients with CHB or hepatitis B in compensation stage were devided into two groups.The patients in group T（25 cases） were treated with intravenous reinfusion of the HBsAg polypeptide-induced DCs and DZW.The patients in group C（20 cases） were treated with DZW only.Therapeutic course was 3 months for both groups.The liver function tests,hepatofibriosis and B-type ultrasonic criteria were examined before and 3 months after treatment.Results Compared to before treatment and group C,the improvements in clinical menifestations,liver functions（AST,ALT and γGT） and the indicators（HA and ⅣC） reflecting hepatofibriosis were all better in group T（P0.05 or P0.01）.So did the effectiveness rate diagnosed by B-type ultragraphy（P0.05）.Conclusion Reinfusion of in vetro autologous HBsAg polypeptide-induced DCs combined with DZW has certain efficacy in the treatment of hepatofibriosis.

关 键 词：肝纤维化 树突状细胞 大黄蛰虫丸 

分 类 号：R575[医药卫生—消化系统]