甘精胰岛素和诺和灵30R对老年2型糖尿病的疗效  

Efficacy of insulin glargine or pre-mixed 30R in the elderly with type 2 diabetes

作　　者：安丽[1] 刘巧玲[2] 李洁[1] 孟云霞[2] 任利群[1] 

机构地区：[1]东南大学附属中大医院老年科,江苏省210009 [2]连云港市第一人民医院

出　　处：《江苏医药》2013年第3期306-308,共3页Jiangsu Medical Journal

摘　　要：目的评价甘精胰岛素或诺和灵30R联合瑞格列奈或阿卡波糖治疗老年2型糖尿病(T2DM)的疗效。方法 T2DM患者87例,年龄>65岁,随机分为甘精胰岛素(A组,42例)和诺和灵30R(B组,45例),观察两组血糖控制情况及患者生存质量。结果治疗第3个月时,A组的血糖达标率高于B组(P<0.05),且前3个月空腹血糖变异系数(CV-FPG)低于B组(P<0.05)。治疗第12个月时A组生存质量评分明显高于B组(P<0.05);A组微血管-周围神经病变总体并发症的发病率明显低于B组(P<0.05)。结论甘精胰岛素联合瑞格列奈或阿卡波糖治疗老年T2DM效果优于诺和灵30R。Objective To compare the efficacy of insulin glargine and pre-mixed 30R plus oral antidiabetic drugs in the elderly with type 2 diabetes mellitus（T2DM）.Methods A total of 87 T2DM patients aged 65 years old was treated with insulin glargine（group A,42 cases） or pre-mixed 30R（group B,45 cases） combined with oral acarbose or repaglinide.The control of blood glucose（BG） and the quality of life（QL） were compared.Results After treated for 3 months,the rate of normal BG of group A was significantly higher than that of group B（P0.05）.The first three months coefficient of variation of fasting BG in group A was significantly less than that in group B（P0.05）.After treated for 12 months,the score of QL was higher,the incidence rate of complications in microvascular and peripheral neuropathy was lower,in group A than that in group B（P0.05）.Conclusion Combined with oral acarbose or repaglinide,insulin glargine is better than pre-mixed 30R in treating T2DM in the elderly.

关 键 词：2型糖尿病 甘精胰岛素 诺和灵30R 老年 

分 类 号：R587[医药卫生—内分泌]