稳定期类风湿性关节炎患者血栓前状态与全身炎症反应关系的研究  

Correlation of systemic inflammatory response with prethrombotic state in patients with stable rheumatoid arthrilis

作　　者：张丽英[1] 傅冠华[1] 徐瑞龙[1] 

机构地区：[1]浙江省金华市中心医院检验科,321100

出　　处：《国际流行病学传染病学杂志》2013年第1期24-26,共3页International Journal of Epidemiology and Infectious Disease

摘　　要：目的通过检测稳定期类风湿关节炎（RA）患者TNF-（~、血小板参数及血管性血友病因子（vWF）、纤维蛋白原（Fg）、D-二聚体（D-D）水平，探讨血栓前状态与全身炎症反应关系。方法选取RA稳定期患者50例和健康对照组50例，测定两组血清中TNF-Q、血管性血友病因子、纤维蛋白原、血小板参数、D-D浓度。结果RA患者TNF-α水平为（2．85±0．4S）ug／L，显著高于正常健康志愿者（t=21．274，P〈0．01）；RA患者vWF、Fg、IND水平分别为（100．57±41．14）％、（4．60±0．65）g／L和（0．33±0．12）mg／L均高于正常健康志愿者，差异有统计学意义（t=3．568、12．422、9．267，P〈0．01）；RA患者TNF-α水平与血小板计数、血小板平均容积、血小板体积分布宽度、大型血小板比例、vWF、Fg、D—D水平呈正相关（r=0．372、0．668、0．585、0．617、0．434、0．653、0．640，P均〈0．01）。结论稳定期RA患者存在全身炎症反应和血栓前状态，稳定期RA患者的全身炎症反应有助于形成血栓前状态。Objective To discuss the relation between prethrombotic state and systemic inflammatory response syndrome by examining the levels of tumor necrosis factor-α （TNF-α）, platelet parameters, von willebrand factor（vWF）, fibrinogen （Fg） and D-dimer （D-D） in patients with stable rheumatoid arthritis （RA）. Methods The levels of TNF-a, platelet parameters, vWF, Fg and D-D were determined in 50 patients with stable RA and 50 healthy persons （control group）, respectively. Results The level of TNF-α in RA group was （2.85±0.48） μg/L. There was a significant difference between RA group and control group （ t = 21.274, P 〈 0.01）. The levels of vWF, Fg and D-D in RA group were （ 100.57 ± 41.14） %, （4.60 ± 0.65） g/L and （0.33 ±0.12） rag/L, which were significantly higher than those in control group（ t = 3.568, 12.422, 9.267, P 〈 0. 01 ）. In RA group, there were significant positive correlations of TNF- level with platelet count, mean platelet volume, platelet distribution width, platelet-large cell ratio, vWF, Fg and D-D levels（r =0.372, 0.668, 0.585, 0.617, 0.434, 0.653, 0.640, P 〈0.01）. Conclusions The systemic inflammatory response syndrome with prethrombotic state exists in patients with stable RA, and contributes to the formation of prethrombotic state in stable RA.

关 键 词：关节炎 类风湿 血栓前状态 肿瘤坏死因子 全身炎症反应 

分 类 号：R593.22[医药卫生—内科学]