青春期PCOS患者甲状腺激素与胰岛素抵抗的关系  

Correlation between thyroid hormone and insulin resistance of adolescent patients with polycystic ovary syndrome

作　　者：余芳[1] 吴绮霞[1] 张遇娴[1] 

机构地区：[1]开平市中心医院妇产科,广东开平529300

出　　处：《中国妇幼健康研究》2013年第1期117-118,共2页Chinese Journal of Woman and Child Health Research

摘　　要：目的 探讨青春期多囊卵巢综合征（PCOS）患者甲状腺激素与胰岛素抵抗的关系。方法收集46例年龄在14～20岁之间，存在胰岛素抵抗的PCOS患者，并收集35例同龄段未合并胰岛素抵抗的PCOS患者作为对照，观察两组患者的甲状腺功能差异。结果两组的甲状腺功能均在正常范围内，无合并甲状腺功能亢进或低下；与非胰岛素抵抗PCOS患者比较，合并胰岛素抵抗的PCOS患者的促甲状腺激素（TSH）水平显著降低（t=2．379，P=0．012），而游离三碘甲状腺原氨酸（FT3）、血清游离甲状腺素（FT4）显著升高，差异均有统计学意义（t值分别为-2．124、-1．868，均P〈0．05）。结论甲状腺功能增强与青春期PCOS患者的胰岛素抵抗存在紧密联系。Objective To explore the correlation between thyroid hormone and insulin resistance （IR） of adolescent patients with polycystic ovary syndrome （PCOS）. Methods Totally 46 cases of PCOS with IR ranging in age from 14 to 20 years were recruited.,Another 35 cases of PCOS without IR aged similar years were chose as controls. The difference in thyroid function between two groups was observed. Results The thyroid function of two groups was in normal range, and no hyperthyrea or hypothyroidism was found. Compared with PCOS patients without IR, PCOS＂ patients with IR had significantly lower thyroid-stimulating hormone （TSH） （t = 2. 379, P = 0. 012 ） and higher level of free triiodothyronine （ FT3 ） and serum free thyroxine （FT4） , and the differences were significant （ t value was - 2. 124 and - 1. 868, resoectivelv, both P 〈 0.05 ）. Conclusion Enhancement of thyroid fimction is closely correlated with IR of adolescent patients with PCOS.

关 键 词：多囊卵巢综合征 预后 甲状腺激素类 荧光免疫测定 

分 类 号：R711[医药卫生—妇产科学]