注射用间苯三酚与6种常用输液的配伍稳定性考察  

Study on the Compatible Stability of Phloroglucinol for Injection in 6 Kinds of Commonly Used Injections

作　　者：刘光斌[1] 赵丽萍[1] 姜芳宁 谢六生 张玉叶[1] 张莉莉[1] 

机构地区：[1]甘肃嘉峪关市酒钢医院药学部,甘肃嘉峪关735100

出　　处：《中国药房》2013年第10期918-920,共3页China Pharmacy

摘　　要：目的:考察注射用间苯三酚与6种常用输液的配伍稳定性。方法:在常温条件下、6h内,采用高效液相色谱法测定注射用间苯三酚在6种输液(5%葡萄糖注射液、10%葡萄糖注射液、0.9%氯化钠注射液、5%葡萄糖氯化钠注射液、乳酸林格氏注射液和转化糖电解质注射液)中的含量变化,同时测定pH值、5-羟甲基糠醛变化,观察溶液颜色变化和可见异物。结果:注射用间苯三酚与6种常用输液配伍后,在6h内pH值和5-羟甲基糠醛基本无变化,有效成分间苯三酚的含量在6h内基本无变化,且无明显颜色和可见异物变化。结论:常温下注射用间苯三酚在6种常用输液中6h内稳定。OBJECTIVE： To study the compatible stability of Phloroglucinol for injection in 6 commonly used injections. METHODS： With in 6 h at normal temperature, HPLC method was used to determine the contents of Phloroglucinol for injection in 6 commonly used injections （5% Glucose injection, 10% Glucose injection, 0.9% Sodium chloride, 5% Glucose saline injection, Lactated Ringer＇s injection and Invert sugar and electrolytes injection）. The changes of pH value and 5-hydroxymethyl furfural were determined, and the change of solution color and visible impurity were also observed. RESULTS ： After mixed with 6 commonly used injection, pH value and 5-hydroxymethyl furfural of Phloroglucinol for injection had no apparent change in 6 h, and the content of phloroglucinol also had no apparent change in 6 h; no color change and visible impurity was observed. CONCLUSIONS： Phloroglucinol for injection is stable in 6 commonly used injections within 6 h at nomal temperature.

关 键 词：注射用间苯三酚 配伍稳定性 高效液相色谱法 

分 类 号：R969.2[医药卫生—药理学]