超临界抗溶剂微粒化的过程调控及应用  

The Regulation and Control of the Supercritical Anti-solvent Process and its Applications

作　　者：况丽[1,2] 赵静[1,2] 黄盼[1,2] 姜浩锡[1,2] 

机构地区：[1]天津大学石油化工技术开发中心,天津300072 [2]天津大学绿色合成与转化教育部重点实验室,天津300072

出　　处：《高分子通报》2013年第2期6-13,共8页Polymer Bulletin

基　　金：国家自然科学基金(No.20976120);天津市自然科学基金(No.09JCYBJC06200)

摘　　要：超临界抗溶剂技术已广泛应用于超导材料、颜料、聚合物、炸药及药物制备等领域,是一种与传统方法相比有很多优点的新型微粒化技术,最主要的优点之一是其过程的可调控性。本文主要介绍了超临界抗溶剂过程及该过程中对粒径及分布、形貌、结晶度等的调控,聚合物机构对颗粒的影响,以及在以聚合物和无机物制备复合粒子方面的应用,并对超临界抗溶剂过程中微粒的成形机理进行了简要的概括,指出了超临界抗溶剂技术在这方面的研究现状及存在的问题,并对其应用前景作了进一步的展望。The supercritical anti-solvent （SAS） technology, as a novel technology for the preparation of micro- and nano-particles, has been widely applied in variety of different fields including： superconductors, color matter, polymers, explosives and pharmaceutical compounds. The review discusses the process and how to simultaneously adjust and control the particle size and its distribution, morphology, crystallinity and so on with this facile approach. And the effects of polymer structure on preparation of fine particles is illustrated. In the present review, the application of SAS in the preparation of composite particles with the polymers as the continuous solid phase or coating solid phase were also focused on. The particle formation mechanism in the SAS process was summarized. The problems in these areas are presented, and the future development are proposed as well.

关 键 词：超临界流体 抗溶剂 复合粒子 过程调控 

分 类 号：TQ460.1[化学工程—制药化工]