过氧苯甲酰凝胶与霜剂的稳定性实验观察  

STUDIES ON STABILITY OF BENZOYLPEROXIDE (BZP) GEL AND CREAM

作　　者：方娟娟[1] 王作英[1] 张秋红[2] 

机构地区：[1]北京医科大学第三医院药剂科 [2]北京职工医学院药学系

出　　处：《北京医科大学学报》1991年第4期317-319,共3页Journal of Peking University(Health Sciences)

摘　　要：用恒温加速试验考察了过氧苯甲酰凝胶与霜剂的化学稳定性。测得两种制剂中过氧苯甲酰分解反应的速度常数,表明凝胶比霜剂稳定。同时进行了低温考察,37℃放置1～3个月,分期取样检验,也证实了凝胶剂的稳定性。结果提示,凝胶剂适于药厂商品化生产。The present paper explores the stability of BZP gel and cream at various temperatures. It was ex-amined with the classical isothermal method. According to Arrhenius rule, the reaction rate constant of BZP gel was k_(37℃)=9.5×10^(-6)hr^(-1), BZPcream was k_(37℃)=5.2×10^(-4)hr^(-1). The shelf life was calculated in t_(0.9) at 37℃ BZP gel was about 1.2years, BZP cream was about 8.3 days. The samples of BZP gel and cream for observation at 37℃ was about 1-3 months. These results show that the BZP gel is more stable than BZP cream, so the BZP gel is suitable forindustrial preparation.

关 键 词：过氧本甲酰 凝胶 霜剂 稳定性 

分 类 号：R927.11[医药卫生—药学]