氧化苦参碱对Ⅰ～Ⅳ型过敏反应的抑制作用  

INHIBITION OF TYPE Ⅰ-Ⅳ ALLERGIC REACTIONS BY OXYMATRINE

作　　者：马俊江[1] 斯拉甫[2] 丁瑛 林志彬[1] 陈学荣[3] 韩春雷[3] 彭庆双 方原[3] 

机构地区：[1]北京医科大学药理学教研室 [2]北京医科大学药理学教研室药理高师班 [3]北京医科大学第三医院皮肤病科

出　　处：《北京医科大学学报》1991年第6期445-447,共3页Journal of Peking University(Health Sciences)

摘　　要：氧化苦参碱腹腔注射可明显抑制大鼠被动皮肤过敏反应(PCA),管内给药可显著抑制亲同种细胞抗体介导的肥大细胞脱颗粒;对反相皮肤过敏反应(RCA),Arthus反应及绵羊红细胞(SRB C)诱导的迟发型过敏反应(DTH)亦有显著抑制作用。Oxymatrine was extracted from Radix sophorae flavescentis. Oxymatrine (60 mg/kg ip) significa-ntly inhibited 48 h homologous passive cutaneous anaphylaxis (PCA) in rats. At concetration of 125,625 μmol/L, Oxymatrine decreased the degranulation rate of mast cells mediated by homocytotropic antibody. It showed a marked suppressive effect on reversed cutaneous anaphylaxis (RCA) and Arthus type reactivity in rats. It also inhibited delayed type hypersensitivity (DTH) to sheep red blood cells (SRBC) in normal mice.

关 键 词：氧化苦参碱 过敏反应 皮肤 

分 类 号：R961[医药卫生—药理学]