纳米氧化铈和生命  

Nano Ceria Relating to Human Life

作　　者：沈岳年[1] 郭金玲[2] 刘阿秋 

机构地区：[1]内蒙古大学化学化工学院,内蒙古呼和浩特010021 [2]呼和浩特职业学院,内蒙古呼和浩特010051 [3]内蒙古医院放射科,内蒙古呼和浩特010021

出　　处：《稀土》2013年第1期77-80,共4页Chinese Rare Earths

基　　金：国家自然科学基金项目资助(20263001)

摘　　要：用光电子能谱(XPS)证明了3 nm～5 nm的氧化铈晶格中含有44%的Ce3+,因而具有较强的还原性;用电子顺磁共振(EPR)证明这种纳米氧化铈具有清除自由基的性质;2009年美国J Colon等的研究团队用体外试验(细胞培养,In Vitro)和无胸腺的裸鼠的体内试验(生命耐久性,In Vivo)证明了在放射线作用下,有3 nm～5 nmCeO2粒子存在情况下正常细胞和组织受到保护。这些研究结果,对人类的癌症治疗提出了新方案,即纳米氧化铈加合适的放疗,可克服放疗过程正常细胞和组织受损的弊病。3 nm～5 nm的氧化铈因能清除体内自由基而又是一种潜在抗衰老剂。本文作者认为要达到Ⅰ期人体试验的要求还应在安全性、有效性和选择性方面做更多的工作,同时展示了一张由本文作者自己制作的3 nm～5 nm的氧化铈的电镜照片。This is a short review concerning nanoceria application in health of mankind. It was shown that about 44% of Ce^3＋ is presented in the lattice of 3 - 5 nm size of cerium oxide by XPS experiment, and thus has stronger reducitibility. By EPR,it demonstrated that such nanoceria possesses oxygen free radical scavenging property. In 2009, J. Colon et al disclosed that normal ceils and normal tissue are protected from radiation - induced cellular oxidative damage in vitro cell culture studies and in vivo studies in which athymic nude mice was as an experiment animal. These studies imply that a new approach of radia- tion therapy for cancer will be realized,in which the-normal cells and normal tissue will be protected by 3 ~ 5 nm ceria during radiation. It is very important when the patient is suffering in the radiation therapy. In addition, 3 - 5 nm ceria will be a agent of anti - oxidant or a anti - old and feeble due to its radical scavenging property. But the anthers of this paper think that more works must be done before I clinical trials, such as safety of CeO2 nanoparticles, effectivity of nanoceria for animals bigger than mice, and selectivity of protection etc. All of these studies will get a deeper understanding of mechanism for 3 - 5 nm ceria nanoparticles in the organism body. At last,a TEM picture of 3 -5nm ceria particles was offered which was prepared by auther of this paper.

关 键 词：纳米氧化铈 活性氧物种 放射性保护 

分 类 号：O614.332[理学—无机化学]